PH敏感性PMAA类水凝胶的合成及性能研究

《PH敏感性PMAA类水凝胶的合成及性能研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、西南交通大学硕士学位论文pH敏感性PMAA类水凝胶的合成及性能研究姓名：单连海申请学位级别：硕士专业：生物化学与分子生物学指导教师：张志斌20080408西南交通大学硕士研究生学位论文第1l页在释药时间上，基本上能够跟微球在结肠内的停留时间相吻合。关键词：“智能’’水凝胶；共混微球；体外释放实验西南交通大学硕士研究生学位论文第1II页Abstract“Intelligent"polymerhydrogelswerethosepolymerswhichcouldrespond、枥也largepropertychangestosmallphysicalorchemicalstim

2、ulationssuchastemperatureandpH，andcouldperformsensing，processingandactuatingfunctions．and“intelligent”polymerhydrogelshaveagoodapplicationstomedicmesandbiotechnologyandtheirpromisingpotentialityofdevelopment．ThepolyacrylicacidsizehydrogelsbelongstothepH·sensitivehydrogels，changingthepnofthe

3、environmentwouldcausethephasechangingofthepolyacrylicacidsizehydrogels．Thepapergivesasystemstudyonthepreparationandthepropertiesofthepolymethacrylicacidhydrogels(PMAA)，First，wesynthesisthepolymethacrylicacidhydrogels，anddetermineditsstructurebyInfraredSpectrum．thenwepreparetheblendmicrosphe

4、resbyblendingthesodiumofpolymethacrylicacidwithsodiumalginate，andweobservetheinternalandexternalstructuresoftheblendmicrospheresbyscanningelectronmicroscope，andgiveastudyontheexternal·load-drugexperiment．Mainresultswereasfollows：1、Weusemethacrylicacidforinitialrawmaterialsbyfreeradicalreact

5、ionynthesisthePMAAhydrogelsat40*Candgivearesearchonhisproperties，Theresultshowedthat：PMAAhydrogelsshowedsignificantlypH—sensitive，andthepHincreased，theswellingde铲eeincreased；However，thecrosslinkingagentcontentincreased，theswellingdegreedecreased．2、Wegiveastudyonthepreparationofsodiumalginat

6、emicrosphereswiththesodiumalginateasmaterial，Theresultshowedthat：Whentheconcentrationofsodiumalginateismorethan2．5％andtheconcentrationofCaCl2ismorethan2．0％，theacquiredsodiumalginatemicrosphereshaveabetterroundresistance西南交通大学硕士研究生学位论文第1V页andstrength，andsodiumalginatemicrospheresshowsbeRersw

7、ellingpropertiesinpn6．8orpH7．4，itsessenceoftheswellingisthattheexchangeofNa+-Ca2+causedsol—gelvariation．3、Byblendingthepolymethacrylicacidsobiumandsodiumalginate，wepreparetheblendmicrospheresandmaketheswellingvariationbetweenpH6．8-7．4inordertomakethedrug