穴位肥大细胞及其颗粒物在针刺镇痛中的作用

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1、穴位肥大细胞及其颗粒物在针刺镇痛中的作用Outline穴位肥大细胞在针刺镇痛效应中的作用穴位胶原纤维在针刺镇痛效应中的作用穴位注射组胺的镇痛效应手针和电针穴位信号的启动机制MastcellsinacupointsandsidewardComparisonofNumberofMCsinZhushanliandnon-acupointsofRatGroupNameMCsNumberSkinMuscleAcupoint（n＝6）34.2±2.512.4±1.4Non-acupoint（n＝6）22.1±1.7*8.5±1.0*THEJOURNALOFSCIENCE&HEAL

2、ING,2008，4（3），170-1771.TherelationshipbetweenmastcellfunctionandacupunctureeffectAnimalmodel：AA(acutearthritis)RatCompleteFreunds’adjuvantAcupointselected：Zushanli(ST36)DST36C1.TherelationshipbetweenmastcellfunctionandacupunctureeffectTreateffect：Easepain，Painthreshold1.Therelationshi

3、pbetweenmastcellfunctionandacupunctureeffectThedegranulationofmastcellsSDRatsTailFlickModelAnatomyPositionofZusanliAcupunctureInjectiondrugsforpreventdegranulationofMCABDEST36CPainthresholdofratwhenshieldmastcelldegranulation1.Therelationshipbetweenmastcellfunctionandacupunctureeffect

4、IDGroupName组别Average±SEM(%)AControl正常对照组–1.9±0.1B1AcupunctureatST36穴位针刺组11.6±0.6*B2AcupunctureatNearby-ST36旁开针刺组8.9±0.3*△△C1InjectionofDSCGatST36色甘酸钠注射组1.7±0.1*△C2InjectionofNaClatST36生理盐水注射组1.4±0.1*△D1AcupunctureafterDSCGatST36色甘酸钠注射＋针刺组6.2±0.4*△△D2AcupunctureafterNaClatST36生理盐水注射＋针刺组8

5、.9±0.4*▲D3AcupunctureoppositesideafterDSCG色甘酸钠注射＋对侧针刺组9.3±0.1*▲▲各组别大鼠痛阈变化率峰值比较（20分钟时）(n=6)Note:*P<0.05vs.GroupA;△P<0.01,△△P<0.05vs.GroupB1;▲P<0.01,▲▲P<0.05vs.GroupD11.TherelationshipbetweenmastcellfunctionandacupunctureeffectGroupName组别MCDegranulationRatio(Average±SEM)(％)SkinMuscleCont

6、rol正常对照组29.2±1.226.3±1.8Acupuncture穴位针刺组48.9±3.9*32.2±3.1**AcupunctureafterDSCG色甘酸钠注射＋针刺组33.7±2.8△28.5±2.3AcupunctureafterNaCl生理盐水注射＋针刺组50.4±2.5*29.7±2.3穴区组织肥大细胞脱颗粒率统计(n=6)Note:*P<0.01,**P<0.05vs.ControlGroup;△P<0.01vs.AcupunctureGroup.ResultsfromExperimentStainingofMastCellsinAcupointo

7、nRatsMuscleSkinBeforeAcupunctureAfterAcupunctureDegranulationofcellsAfterSDCGStabilizedTHEJOURNALOFSCIENCE&HEALING,2008，4（3），170-177WhatisthekeyfactortodegranulationTheacupunctureeffectispositiverelationshiptothedegranulationofmastcellatacupoint.Whatiskeyfactorconducethedegranu