资源描述：
《Osteoblast adhesion to functionally graded hydroxyapatite coatings》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、Osteoblastadhesiontofunctionallygradedhydroxyapatitecoatingsdopedwithsilver121StefanSandukas,AkikoYamamoto,AfsanehRabiei1DepartmentofMechanicalandAerospaceEngineering,NorthCarolinaStateUniversity,911OvalDrive,EngineeringBuildingIII,Box7910,Raleigh,NorthCarolina276952
2、BiomaterialsCenter,NationalInstituteforMaterialsScience,1-1Namiki,Tsukuba,Ibaraki,305-0044JapanReceived21August2010;revised13January2011;accepted19January2011PublishedonlineinWileyOnlineLibrary(wileyonlinelibrary.com).DOI:10.1002/jbm.a.33081Abstract:Silver-dopedfunct
3、ionallygradedhydroxyapatiteingsurfacesbeforeandafterimmersioninhigh-puritywater,(Ag-FGHA)coatingshavebeenpreparedonglassandtita-showingthatallsurfacesinitiallyhadroughnessaveragesniumsubstratesbyionbeamassisteddeposition(IBAD)below200nm,whileafterimmersion,roughnessa
4、verageofmethodwithinsituheattreatment,andthebiologicalFGHA-Ag1surfacewassignificantlyincreased(Ra¼404þ/responseanddissolutionpropertiesofthecoatingshave100.8nm),attributedtothehighestrateofdissolution.þbeenexamined.ThreeAg-FGHAcoatingswithdifferentper-ReleaserateofAg
5、ionsinsolutionwasmeasured,showingcentagesofsilver(1,3,and6.6wt%Ag)werecomparedreleaseratesofsilverionsforallAg-dopedcoatingswereini-withpureFGHA(withoutAg)asacontrol.MC3T3-E1murinetiallyhighandthengraduallydecreasedtoaminimumoverosteoblastcellswereculturedonFGHAandAg
6、-FGHAcoatingtime,whichistheexpecteddissolutionoffunctionallygradedsurfaces,andthenumberofadheredcellsafter1,4,and7coatings.ItisconcludedthatFGHA-Ag1coatingpromoteddayswascounted.Micromanipulationoflivesinglecellswasthehighestdegreeofosteoblastadhesionbecauseofoptimal
7、performedtoquantitativelycomparecellaffinityamongthedissolutionrateandnontoxicAgpercentage.VC2011WileyPeri-fourcoatingcompositions.ResultsshowedthatFGHA-Ag1odicals,Inc.JBiomedMaterResPartA:00A:000–000,2011.coating(with1wt%Ag)hadthehighestnumberofadheredcellsaftereachi
8、ncubationperiod,aswellasthehighestcellaffinityafter24-hincubation.Surfaceprofilometrywasper-KeyWords:hydroxyapatitecoating,osteoblast
