Aβ25-35致PC12细胞凋亡和线粒体跨膜电位损伤关系研究

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1、四川生理科学杂志2011；33(1)GastroenterolSuppl，1985，112：12-19．pressor[Jq．NatRevCancer，2003，3(5)：350-361．1OUludag0，TunctanB，AltugS，eta1．Twenty-four-hourvariation14WatanabeA，HamadaT，ShibataS，eta1．EffectofnitricoxideofL-arginine／nitricoxide／cyclicguanosinemonophosphatepathwaysyntba

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5、angenePr1expressioninratpancreaticacinusAR42JcelllinesTianGuo-hua，YangYu-ting，ZhangHui-qin，JiangZhou，WangYu-hui，WangZheng-ronga(KeyLaboratoryofChronobiology，MinistryofHealth，WestChinaSchoolofPreclinicalandForensicMedicine，SichuanUniversity，SichuanChengdu610041)Abstract

6、Objective：TostudytheeffectsofL-Arginineoncircadiangenejr1expressioninratpancreaticacinusAR422eelllines．Methods：TheculturedAR42JcellswereinducedwithPMAtoexpresscircadiangenes．Aftertheexpressionofr1RNAap—pearedstablecircadianrhythm，thecellsweredividedintotheexperimentalg

7、roupandcontrolgroup．TheexperimentalgroupwasaddedwiththeculturemediumcontainingL-ArginineandtI1econtrolgroupwasaddedwithequalvolumeofculturemediumwithoutL-Arginine．The1RNAexpressionatdifferenttimewasmeasuredinAR42JcellswithRT—PCRReslIlts：RT-PCRresultsshowthattheexpressi

8、onofR，r1mRNAdecreasedsignificantilyinexperimentalgroup，comparedwithcontro1gmup(P—O．038)．Conclu-sion：L-Argininecandecr