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1、ThenewenglandjournalofmedicinespecialreportAtypicalHyperplasiaoftheBreast—RiskAssessmentandManagementOptionsLynnC.Hartmann,M.D.,AmyC.Degnim,M.D.,RichardJ.Santen,M.D.,WilliamD.Dupont,Ph.D.,andKarthikGhosh,M.D.Breastbiopsiesarecommonlyperformedtoeval-includedinmanyhigh-riskguideli
2、nes.Forex-uatemammographicorpalpablefindingsthatample,screeningmagneticresonanceimagingareofconcern,andthemajorityrevealbenign(MRI)isnotroutinelyrecommendedforthesefindings.Morethan1millionofthebreastbiop-women.16Inaddition,studiesoftheuseofche-siesthatareperformedannuallyintheU
3、nitedmopreventiveagentsshowthatonlyasmallmi-Statesarefoundtobebenign.1Onthebasisofnorityofhigh-riskwomentakethesedrugs,17thehistologicfindings,itispossibletostratifydespiterandomizedclinicaltrialsshowingsub-womenwithbenignbiopsyfindingsintogroupsstantialbenefitspecificallyforwom
4、enwithwithsignificantlydifferentrisksoflaterbreastatypicalhyperplasia.cancer.2,3Atypicalhyperplasiaisahigh-riskbe-Becauseofthehigh-riskfeaturesandhighnignlesionthatisfoundinapproximately10%incidenceofatypicalhyperplasiaandtheavail-ofbiopsieswithbenignfindings.4Inthisarticle,abil
5、ityofeffectivebreast-cancerpreventionstrat-weexaminethesebenignlesionsbecausetheyegies,atypicalhyperplasiaisthebenignbreasthavespecialimportanceasapredictoroffuturediagnosisthatismostimportanttoactonclini-breastcancer.Therearetwotypesofatypicalcally.Inthisreport,wedescribethehis
6、tologichyperplasia,asclassifiedonthebasisofmicro-andmolecularfeaturesofatypicalhyperplasia,scopicappearance:atypicalductalhyperplasiathecurrentmanagementofthecondition,newandatypicallobularhyperplasia;theseoccurdataonthecumulativeriskofbreastcancerwithequalfrequencyandconfersimi
7、larrisksofamongwomenwithatypicalhyperplasia,cur-laterbreastcancer(Table1).2,3,9,10Thus,through-rentguidelines,andsuggestionsformoreinten-outthisarticle,thevarietieswillbereferredtosivescreeningandpreventionstrategiesbasedtogetheras“atypicalhyperplasia.”onaccurateriskestimates.In
8、atypicalhyperplasia,thereisaprolifera-tionofdys
