[2006] Electrophoresis - Ionic dispersion in nanofluidics

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1、Electrophoresis2006,27,4999–50084999AngelaDeLeebeeckResearchArticleDavidSintonDepartmentofMechanicalIonicdispersioninnanofluidicsEngineering,UniversityofVictoria,VictoriaB.C.,CanadaAnanalyticalsolutionfordispersionofionicandneutralsolutesinnanoscalechannels

2、ispresented.Resultssuggestthatinthepresenceofrelativelythickelectricaldoublelayers(EDLs)characteristicofnanofluidics,thedispersionofionicsolutesdiffersfromReceivedApril28,2006thatofneutralsolutesonwhichprevioustheoryisbased.IonicdispersionforcircularRevised

3、August1,2006cross-sectionchannelsisquantifiedasafunctionofavalanceparameter,therelativeAcceptedAugust27,2006EDLthickness,andtheformofthevelocityprofile.Twouniquemechanismsgoverningionicdispersioninbothpressure-andelectrokineticallydrivenflowsareidentified.T

4、heresultsoftheanalyticalsolution,employingthelinearizedformofthePoisson–Boltz-mannequation,aresupportedandextendedbytheresultsofanindependentcom-putationalmodelemployingthenonlinearPoisson–Boltzmannequation.Applicabilityofthecomputationalresultsisnotlimited

5、bytheDebye–Hückelapproximation.Col-lectively,theseresultsindicatethatdispersionofionicspeciesinnanoscalechannelsismarkedlychargedependent,andsubstantiallydeviatesfromthatofneutralsolutesinthesameflow.Keywords:Dispersion/Electrokinetic/Ionicdispersion/Nanoch

6、annels/Nano-fluidicDOI10.1002/elps.2006002641Introductionemergedsuchasmacromolecularseparationinorderedpostarrays[6],andentropictraps[7].Morerecently,Thestudyandapplicationoffluidflowinandaroundnanoscaleelectrophoreticseparationmethodshavebeennanostructures

7、,ornanofluidics,presentsuniqueoppor-developed[8–10].Theextensionofelectrophoretictunitiesforbiologicalandchemicalanalysis[1].Incon-separationmethodsfrommicrochannelstonanochannelstrasttomanymicrofluidicapplicationswheretheelec-haspotentialforincreasedfields

8、trengthsandassociatedtricaldoublelayer(EDL)atthesolid–liquidsurfacecanbeincreasedspeedofanalysisandsensitivity.Perhapsmoreapproximatedbyaninfinitelythinlayer,nanofluidicsimportantly,charge-specificinte