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1、ChemSocRevViewArticleOnlineREVIEWARTICLEViewJournal
2、ViewIssueSyntheticmicrobialconsortia:fromsystematicanalysistoconstructionandapplicationsCitethis:Chem.Soc.Rev.,2014,43,6954HaoSong,Ming-ZhuDing,Xiao-QiangJia,QianMaandYing-JinYuan*Syntheticbiologyisanemergingresearchfieldthatfocusesonusing
3、rationalengineeringstrategiestoprogrambiologicalsystems,conferringonthemnewfunctionsandbehaviours.Bydevelopinggeneticpartsanddevicesbasedontranscriptional,translational,post-translationalmodules,manygeneticcircuitsandmetabolicpathwayshadbeenprogrammedinsinglecells.Extendingengineeringcapabi
4、litiesfromsingle-cellbehaviourstomulticellularmicrobialconsortiarepresentsanewfrontierofsyntheticbiology.Herein,wefirstreviewedbinaryinteractionmodesofmicroorganismsinmicrobialconsortiaandtheirunderlyingmolecularmechanisms,whichlaythefoundationofprogrammingcell–cellinteractionsinsyntheticmi
5、crobialconsortia.Systemsbiologystudiesoncellularsystemsenablesys-tematicunderstandingofdiversephysiologicalprocessesofcellsandtheirinteractions,whichinturnofferinsightsintotheoptimaldesignofsyntheticconsortia.Basedonsuchfundamentalunderstanding,acomprehensivearrayofsyntheticmicrobialconsort
6、iaconstructedinthelastdecadewerereviewed,includingisogenicmicrobialcommunitiesprogrammedbyquorumsensing-basedcell–cellcommunica-tions,sender–receivermicrobialcommunitieswithone-waycommunications,andmicrobialecosystemswiredbytwo-way(bi-directional)communications.Furthermore,manyapplicationsi
7、ncludingusingReceived23rdMarch2014syntheticmicrobialconsortiafordistributedbio-computations,chemicalsandbioenergyproduction,DOI:10.1039/c4cs00114amedicineandhumanhealth,andenvironmentswerereviewed.Synergisticdevelopmentofsystemsandsyntheticbiologywillprovidebothathoroughunderstandingofnatur
8、allyoccurringmicrobialconsortiawww.rsc.org/csrandrationalengineeringofthesecomplicatedconsortiafornovelapplications.1.IntroductionPublishedon14July2014.DownloadedbyTsinghuaUniversityon08/01/201509:32:50.KeyLaboratoryofSystemsBioengineering,MinistryofEduc
