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1、中国组织工程研究与临床康复第14卷第40期2010–10–01出版JournalofClinicalRehabilitativeTissueEngineeringResearchOctober1,2010Vol.14,No.40人脐带间充质干细胞不同输注途径对急性肾小管坏死的影响☆11，2111李芳，胡祥，赵红梅，贾丹兵，党智杰Influenceofdifferentinfusionmethodsofhumanumbilicalcordmesenchymalstemcellsonacutetubularnec
2、rosis11,2111LiFang,HuXiang,ZhaoHong-mei,JiaDan-bing,DangZhi-jieAbstract1BACKGROUND:StudieshaveconfirmedthatexogenousmesenchymalstemcellscanmigrateandestablishinthenephridialDepartmentofNephrology,the211tissuefollowingischemia/reperfusioninjury,differentiate
3、intorenaltubularepithelialcells,andrecoverstructureandfunctionoftheHospitalofChinesekidney.Atpresent,itiscontroversialwhichisbetter,arterialinjectionorintravenousinjection,fortransplantingstemcells.PLA,HarbinOBJECTIVE:Toobservetheeffectsofdifferenttransplan
4、tationmethodsofhumanumbilicalcordmesenchymalstemcellson150086,Heilongjiangdogswithacutetubularnecrosis(ATN).Province,China;2ShenzhenBeikeMETHODS:HealthydogmodelsofATNwereestablishedandrandomlydividedintotwogroups.HumanumbilicalcordderivedCellsEngineeringmes
5、enchymalstemcellswerelabeledwithDAPI.ThenthecellswereinjectedthroughperipheralveinsandrightfemoralarteryResearchInstitute,intomodeldogs’body.24hourslater,histologicalchangeswereobservedbylightmicroscope,andthesurvivalofhumanumbilicalShenzhen518000,cordmesen
6、chymalstemcellswasevaluatedbyfluorescentmicroscope.GuangdongProvince,RESULTSANDCONCLUSION:Undercommonopticalmicroscope,pathologicalchangessuchasswelling,degenerationandChinanecrosisappearedinrenaltubularepithelialcellsinbothgroups.Theinjectedhumanumbilicalc
7、ordmesenchymalstemcellscouldLiFang☆,Doctor,surviveintheaffectedkidney.Therewasnosignificantdifferenceonfluorescenceintensitybetweentwogroups(P>0.05).TheseChiefphysician,indicatedthattransplantedhumanumbilicalcordmesenchymalstemcellsbytwopathwayscansurvivein
8、thekidneys.TheDepartmentofoutcomesweresimilarinrepairingthekidney.Comparedwitharterialinjection,thetransplantationofintravenousinjectionNephrology,the211obtainedlittletrauma.HospitalofChinesePLA,Harbin
