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1、Availableonlineatwww.sciencedirect.comFoodandChemicalToxicology46(2008)446–475www.elsevier.com/locate/foodchemtoxReviewBiologicaleffectsofessentialoils–Areviewa,baa,*bF.Bakkali,S.Averbeck,D.Averbeck,M.IdaomaraInstitutCurie-SectiondeRecherche,UMR2027CNRS/IC,LCRV28CEA,Baˆt.110,CentreUniversitaire,
2、91405Orsaycedex,FrancebUniversite´AbdelmalekEssaˆadi,Faculte´desSciences,LaboratoiredeBiologieetSante´,BP2121,Te´touan,MoroccoReceived29December2006;accepted21September2007AbstractSincethemiddleages,essentialoilshavebeenwidelyusedforbactericidal,virucidal,fungicidal,antiparasitical,insecticidal
3、,medicinalandcosmeticapplications,especiallynowadaysinpharmaceutical,sanitary,cosmetic,agriculturalandfoodindustries.Becauseofthemodeofextraction,mostlybydistillationfromaromaticplants,theycontainavarietyofvolatilemoleculessuchasterpenesandterpe-noids,phenol-derivedaromaticcomponentsandaliphati
4、ccomponents.Invitrophysicochemicalassayscharacterisemostofthemasanti-oxidants.However,recentworkshowsthatineukaryoticcells,essentialoilscanactasprooxidantsaffectinginnercellmembranesandorganellessuchasmitochondria.Dependingontypeandconcentration,theyexhibitcytotoxiceffectsonlivingcellsbutareusual
5、lynon-genotoxic.Insomecases,changesinintracellularredoxpotentialandmitochondrialdysfunctioninducedbyessentialoilscanbeasso-ciatedwiththeircapacitytoexertantigenotoxiceffects.Thesefindingssuggestthat,atleastinpart,theencounteredbeneficialeffectsofessentialoilsareduetoprooxidanteffectsonthecellularlev
6、el.Ó2007ElsevierLtd.Allrightsreserved.Keywords:Essentialoil;Cytotoxicity;Genotoxicity;Antigenotoxicity;ProoxidantactivityContents1.Introduction.............................................................................4472.Chemicalcomposition...................................................
7、...................4472.1.Terpenes.............................................................................4492.2.Aromaticcompounds...................................................................4493.Biologicaleffects......
