合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预后.pdf

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1、201420783合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预后何唐艳导师姓名：梁华晟专业名称：内科学申请学位类型：专业学位答辩委员会主席：秦映芬答辩委员会委员：梁杏欢苏会璇吕建楠洪冬玲二○一七年五月目录合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预1后2014级硕士研究生论文T2DMType2diabetesmellitus2HDBCHormone-dependentbreastcancerT2DMHDBCCombinationoftype2diabetesmellitus2hormone-dependentbreastcancerSHDBCSimplehormo

2、nedependentbreastcancerADATheAmericanDiabetesAssociationAJCCAmericanjointcommitteeoncancerEREstrogenreceptorPRProgesteronereceptorHER-2Humanepidermalgrowthfactorreceptor-22BMIBodyMassIndexOSOverallsurvivalPFSProgression-freesurvivalIGFsnsulin-likegrowthfactorsIGF-/nsulin-likegrowthfactors-/

3、-/IGF-IR/Rnsulin-likegrowthfactors-/receptors-/EMTEpithelial-mesenchymaltransitionCaspaseCysteinylaspartatespecificproteinaseAMPKAdenosine5-monophosphate-activatedproteinkinasePI3KPhosphatidylinositol3-kinase3MAPKsMitogen-activatedproteinkinasesMMPMatrixmetalloproteinaseERKExtracellularregu

4、latedproteinkinasesSTATSignaltransducerandactivatoroftranscription1合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预2后2014级硕士研究生论文合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预后摘要±2合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预3后2014级硕士研究生论文关键词3合并2型糖尿病的激素依赖型乳腺癌患者的临床特点及预4后2014级硕士研究生论文CLINICALCHARACTERISTICSANDPROGNOSISOFHORMONE-DEPENDENTBREASTCANCERPATIENT

5、SWITHTYPE2DIABETESMELLITUSABSTRACTObjectiveToinvestigatetheclinicalcharacteristicsandprognosisofpatientswithhormone-dependentbreastcancercomplicatedwithtype2diabetesmellitusandtheeffectofmetforminontheprognosisofpatientswithtype2diabetesmellitus.MethodsAtotalof34womenwithhormone-dependentbr

6、eastcancerwithtype2diabetesmellituswereenrolledintheFirstAffiliatedHospitalofGuangxiMedicalUniversityfromOctober2012toMarch2017,and34patientswithhormone-dependentbreastcancerwithtype2diabetesmellitusFemalepatientswerehospitalizedatthesametime,andtheagedifferenceof±5yearsoldnon-combinedtype2

7、diabetesmellitussimplehormone-dependentbreastcancerinfemalepatientswererandomlyselectedbyexcelrandomnumber.Inaddition,accordingtotheuseofmetformincombinedwithtype2diabeteshormone-dependentbreastcancerpatientsweredividedintometformin4合并2型糖尿病的激素依赖型乳腺癌患者的临床