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1、JournalofMedicalVirology16:67-76(1985)Human-Enteric-CoronaviruslikeParticles(CVLP)WithDifferentEpidemiologicalCharacteristicsMarcSitbonCentreInternationaldeRecherchesMedicalesdeFranceville,Franceville,GabonOnehundredfifty-sixdiarrheicand115controlstoolscoll
2、ectedthroughoutayearfromnonhospitalizedchildrenwereexaminedbyelectronmicroscopyinHaut-OgoouC,Gabon;65.2%ofthecontrolsand38.5%ofthediarrheicswerefoundtocontaincoronaviruslikeparticles(CVLP).InbothdiarrheicandcontrolgroupstheCVLPprevalencesshowedaseasonalvari
3、ationwhereassignificantvariationofprevalencewithagewasobservedonlyinthecontrols.Thus,theCVLPincontrolsweresignificantlymoreabundantinchildrenover2yearsold(76%vs48%,P<.01)andmorefrequentlyobservedduringthemonthsofrainyseasons(75%vs54%,P<.02).Ontheotherhand,t
4、hehigherprevalenceofCVLPindiarrheicsover2yearsoldwasnotsignificant(48%vs36%,P=.20),whereasasignificantlylowerprevalenceofCVLPduringthemonthsofrainyseasonswasobservedinthisgroup(27%vs50%,P<.01).Studiesoftheclimatologicalfactorsinthisequatorialclimateshowedap
5、arallelcyclicalvariationofparametersrepresentingrainfall,temperature,aswellasrelativehumidity.WewerenotabletodistinguishwhichofthesefactorswasinfluencingmoredirectlytheprevalenceofCVLP.Keywords:diarrhea,coronaviruses,human,seasonalprevalence,GabonINTRODUCTI
6、ONTheroleofcoronavirusesingastroenteritishasbeenextensivelystudiedinanimals,fromwhichseveralstrainscausingdiarrheahavebeenisolatedfromdifferentspecies[Garwes,19821.Sincethefirstelectronmicroscopic(EM)examinationsofhumanentericparticlesresemblingcoronaviruse
7、sinIndia[Mathanetal,19751andinEngland[Cauletal,19751,coronaviruslikeparticles(CVLP)[MacnaughtonandDavies,19811havebeensuspectedtocauseseveralsortsofoutbreaksofgastroenter-itisinhumans[Chanyetal,1982;Vaucheretal,19821.However,conflictingdataAcceptedforpublic
8、ationDecember6,1984.Dr.Sitbon’spresentaddressisLaboratoryofPersistentViralDiseases,RockyMountainLaboratories,HamiltonMT59840.AddressreprintrequeststoDr.MarcSitbon,RockyMountainLaboratories,HamiltonMT59
