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1、PGfentReportThissectionprovidesinformationonworldwidepatentsconstructionbyinsertionofglycoproteingenefromforeignherpesrelevanttovaccinedesignandproduction.ThePatentReportvirus,pseudorabiesvirus,Epstein-Barrvirusorcytomegalovirusgivesthefollowinginformation:titleofpatent,patentee,pat
2、entHealth-Resnumber,publicationdateandsummaryofthepatent.AnumberWorld9012882;1November1990ofpatentsinthisreportarereproducedfrom'BiotechnologyArecombinantpoxviruscontainingglycoproteingpl3andAbstracts'withpermissionofDerwentPublicationsLtd,gpl4genesfromahorseherpesvirusinanonessenti
3、alregionRochdaleHouse,128TheobaldsRoad,LondonWC1X8RP,ofthepoxvirusgenomeisclaimed.TherecombinantvirusisUK.preferablyvacciniavirus,oranavipoxviruse.g.canary-poxvirusorfowl-poxvirus,andmaycontainone,twoorthreeglycoproteingenes.TheforeignDNAinsertpreferablycontainsSynthesisofdimericLex
4、ordifucosylY2cancerantigen;usefulapromoterand~,flor7-herpesvirusDNAencodinggpl3,asantitumorvaccineandtosubsideinflammatoryprocessesofgpl4,gD,gp63orgE,pseudorabiesvirusgp50,gplI,gplIIorrheumatoidarthritis;preparationusing~,I-3-fucosyltransferasegpI,herpessimplexvirusgB,gCorgD,cattleh
5、erpesvirusgIBiomembrane-lnstorcatherpesvirusgB,Epstein-Barrvirusgp220,gp340,gBorEur.395217;31October1990gHorhumancytomegalovirusgBglycoproteingenesandisTheproductionofdifucosylY2(dimericLex)comprises:introducedintothepoxvirusgenomebyrecombination.Thei.preparingalactonorhexaosylceram
6、ide(I)backboneorarecombinantpoxvirusmaybeexpressedinahostforthelactonorhexaosylsaccharide(II)backbonelinkedtoacarrierproductionofrecombinantglycoproteins.Therecombinantpoxmolecule;andii.enzymaticallyfucosylatingthebackboneatvirusmaybeusedasarecombinantvaccinetoavoidmaternalthe1113an
7、dV3positionsthroughanct1-3linkage.Alsoclaimedimmunityinnewbornoffspring.MethodsforavoidingmaternalistheproductionofLeyantigenanalogsby:a.as(i.)to(ii.);immunitybyusingtwonewrecombinantvaccinescontainingb.enzymaticallyfucosylatingthebackboneattheterminaldifferentglycoproteingenestoimm
8、unizethemotherandth
