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1、VIROLOGICASINICA2016,31(1):1–2DOI:10.1007/s12250-016-3746-0EDITORIALCoronavirus:epidemiology,genomereplicationandtheinteractionswiththeirhostsZheng-LiShi1*,DeyinGuo2*,PeterJ.M.Rottier3*1.KeyLaboratoryofSpecialPathogens,WuhanInstituteofVirology,ChineseAcademyofScience
2、s,Wuhan430071,China2.StateKeyLaboratoryofVirology,CollegeofLifeSciences,WuhanUniversity,Wuhan430070,China3.VirologyDivision,DepartmentofInfectiousDiseasesandImmunology,FacultyofVeterinaryMedicine,UtrechtUniversity,Utrecht3584CL,NetherlandsThis special issue of the jo
3、urnal isthat provides new insight into thepivotal for drug screening and vac-dedicated to the recent progress onepidemiology of coronaviruses (Yipcine development against the dis-coronaviruses and covers the topicset al., 2016). Niu etal. present theeases caused by c
4、oronaviruses. Inof viral epidemiology, virus replica-development of a new two-tube mul-this issue, Chen and Guo give antion and the interactions between thetiplex real-time reverse transcriptionoverview of recent progresses oncoronaviruses and their hosts.PCR to dete
5、ct six human coronavir-molecular mechanisms of coronavir-Members of the family Coronavi-uses (Niu et al., 2016). Three art-us RNA capping and methylationridaeinfect a wide range of verteb-icles, authored by Ge etal., Xu etal.(Chen et al., 2016). Wang etal.,rates and
6、humans. They usuallyand Wang etal., describe differentsummarize the recent advances incause respiratory, gastrointestinal,discoveries on more diverse batbiological and structural studies, to-hepatic and/or central nervous sys-coronaviruses including SARS-likegether w
7、ith the development of in-tem diseases of humans, livestockcoronaviruses, highlighting the im-hibitors targeting coronavirus pro-and wild animals. Prior to the out-portance of continued further re-teases (Wang et al., 2016).break of severe acute respiratory sy-search
8、 on bat-related coronavirusesZoonotic coronaviruses are be-ndrome (SARS), only two corona-(Ge et al., 2016; Wang et al., 2016;comin
