结直肠黏液腺癌淋巴结转移度的临床病理意义.doc

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1、结直肠黏液腺癌淋巴结转移度的临床病理意义［摘要］目的探讨结直肠黏液腺癌淋巴结转移度的临床病理意义。方法收集2011年1月一2013年12月该院收治的26例结直肠黏液腺癌患者临床病理资料，根据性别、年龄及肿瘤部位进行分组，病理诊断确定各组术后标本收获淋巴结数及有肿瘤转移的阳性淋巴结数，按照淋巴结转移度二（阳性淋巴结数/收获淋巴结数）X100%,计算淋巴结转移度并进行统计学比较。结果26例结直肠黏液腺癌中，男性患者淋巴结转移度（37.29%）明显高于女性（14.29%）；65岁以上患者淋巴结转移度（40.63%）明显高于65岁以下（19.29%）；左半

2、结肠和直肠肿瘤患者淋巴结转移度（46.59%）明显高于右半结肠（21.11%）,差异有统计学意义（P〈0.001）。结论结直肠黏液腺癌淋巴结转移度与患者性别、年龄及肿瘤部位有关。［关键词］结直肠癌；黏液腺癌；淋巴结转移度［中图分类号］R735.3［文献标识码］A［文章编号］1674-0742（2014）10（b）-0042-03ClinicopathologicalSignificanceofLymphNodeMetastasisRatioinColorectalMucinousAdenocarcinomaLILiWANGJinsongZHAOJi

3、anhuaDepartmentofPathology,NanjingFirstHospitalAffiliatedtoNanjingMedicalUniversity，Nanjing，JiangsuProvince,210006,China[Abstract]ObjectiveToinvestigatetheclinicopathologicalsignificanceoflymphnodemetastasisratioincolorectalmucinousadenocdtcinoma.MethodsTheclinicopathologicald

4、ataof26caseswithcolorectalmucinousadenocarcinomaadmittedinourhospitalfromJanuary2011toDecember2013werecollected・Andthepatientsweredividedintodifferentgroupsaccordingtothesex,ageandtumorlocation.Thenumberofinvadedlymphnodesandthetotalnumberofresectedlymphnodesinsurgicalspecimen

5、swerediagnosedbypathologists.Thelymphnodemetastasisratio,whichistheratiobetweenthenumberofinvadedlymphnodesandthetotalnumberofresectedlymphnodes,wereanalyzedstatistically.ResuItsOfthe26caseswithcolorectalmucinousadenocarcinoma,thelymphnodemetastasisratioinmales(37.29%)wassigni

6、ficantlyhigherthanthatinfemales(14.29%)；andthatin65yearsorolder(40.63%)wasobviouslyhigherthanthatinunderage65(19.29%)；thatinlefthemicolonandrectalcancer(46・59%)wasmuchhigherthanthatinrighthemicolon(21.11%)，thedifferenceswerestatisticallysignificant(P<0.001)・ConclusionThelymphn

7、odemetastasisratioofcolorectaimucinousadenocarcinomaiscorrelatedwiththesex,ageandtumorlocationofpatient・[Keywords]Colorectaicancer；Mucinousadenocarcinoma；Lymphnodemetastasisratio结直肠癌是消化道常见的恶性肿瘤之一，其发病率居恶性肿瘤发病率第三位。作为结直肠癌的病理组织学亚型，黏液腺癌和印戒细胞癌在形态学上都呈现大量黏液分泌，但是黏液腺癌表现为细胞外黏液的分泌亢进，印戒细胞癌

8、则表现为细胞内黏液潴留，而且二者的分子机制也可能不同。在结直肠癌的发生发展过程中，黏液腺癌和印戒细胞癌的恶性转化途径可能与