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1、生理学报ActaPhysiologicaSinica,October25,2004,56(5):597-602597http://www.actaps.com.cn研究论文帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化褚玉霞1,刘健1,2,*,冯洁1,王勇3,张巧俊3,李强11西安交通大学医学院生理学教研室;2环境与疾病相关基因教育部重点实验室,西安710061;3西安交通大学第二医院神经内科,西安710004摘要:实验采用玻璃微电极细胞外记录法,观察了帕金森病(Parkinson’sdisease,PD)大鼠中
2、缝背核(dorsalraphenucleus,DRN)5-羟色胺(5-hydroxytrypamine,5-HT)能神经元电活动的变化。结果发现,对照组和PD组大鼠DRN中5-HT能神经元的放电频率分别为(1.61±0.56)Hz和(2.61±1.97)Hz,PD组大鼠的放电频率显著高于对照组(P<0.05)。在对照组大鼠,79%的神经元呈现规则放电,21%为爆发式放电；在PD组大鼠，具有规则、不规则和爆发式放电的神经元比例分别为36%、16%和47%,爆发式放电的5-HT能神经元比例明显高于对照组(P<0.05)。结果表明，帕
3、金森病大鼠DRN中5-HT能神经元的放电频率增高,且爆发式放电增多。关键词:帕金森病;中缝背核;5-羟色胺;6-羟多巴胺;电生理学;大鼠中图分类号:Q462;R338.2+2Changesofdischargerateandpatternof5-hydroxytrypamineneuronsofdorsalraphenucleusinaratmodelofParkinson’sdiseaseCHUYu-Xia1,LIUJian1,2,*,FENGJie1,WANGYong3,ZHANGQiao-Jun3,LiQiang11Dep
4、artmentofPhysiology,SchoolofMedicine,Xi’anJiaoTongUniversity;2KeyLaboratoryofEnviormentandGenesRelatedtoDiseases,Xi’an710061,China;3DepartmentofNeurology,theSecondHospital,Xi’anJiaoTongUniversity,Xi’an710004,ChinaAbstract:Inthepresentstudy,changesoftheneuronalactivit
5、yof5-hydroxytrypamine(5-HT)neuronsofdorsalraphenucleus(DRN)inaratmodelofParkinson’sdisease(PD)wereinvestigatedwithglassmicroelectroderecording.Theresultsshowedthatthedischargeratesof5-HTneuronsincontrolandPDratswere(1.61±0.56)Hzand(2.61±1.97)Hz,respectively.Thedischa
6、rgerateofPDratswassignificantlyincreasedwhencomparedtothatofthecontrolrats.Incontrolrats,79%of5-HTneuronsdischargedregularlyand21%inbursts.InPDrats,however,36%of5-HTneuronsdischargedregularly,16%irregularlyand47%inbursts.Thepercentageof5-HTneuronsdischarginginburstsw
7、asobviouslyhigherthanthatofthecontrolrats(P<0.05).Thedatasuggestthatthedischargerateandburstingpatternof5-HTneuronsinDRNareincreasedinaratmodelofParkinson’sdisease.Keywords:Parkinson’sdisease;dorsalraphenucleus;5-hydroxytrypamine;6-hydroxydopamine;electrophysiology;r
8、at帕金森病(Parkinson’sdisease,PD)是由于黑质致能改变。在PD动物和PD患者均发现基底神经节环密部多巴胺能神经元进行性的变性而产生的神经退变路的间接通路中底丘脑核(subthalamicnucleus,STN)[1,2]性疾病。多巴胺能神经
