eif4e在食管鳞状细胞癌中表达及其与预后关系的研究

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1、现代肿瘤医学2014年2月第22卷第2期MODERN0NCOLOGY，Feb2014，V0L22，N0，02．317Surg，2004，25(3)：44344810]李嫒，杨志刚，陈天武，等周围型肺腺癌与鳞癌64层螺旋cT9]I[flotoH．OsakiT．TagaS．alVascm⋯nd()*helialoyahn叫首过时间灌注特征对比研究[J]生物医学工程学杂志，exat~onlnnonsmancelIlungcance：pro~nos*icslgnl“2009，26(2)：298302can⋯nsquamouscellc~mnoma『J]JTh~acC盯dlovasc

2、Surg(编校：徐萌)1qqR11f、1nn71n14eIF4E在食管鳞状细胞癌中表达及其与预后关系的研究刘月平，温文娟，王续，杨会钗，王小玲elF4EexpressionandifscorrelationwithprognosisinesophagealsquamouscellcarcinomaⅡuYueping，WenWenjuan，WangXu，YangHumhsi，WangXiaolingDepartmentPathology，theFourthHospitalofHebdMedicalUnivers，HebeiShijiad~uang050011，China【Ab

3、stract】Objective：ToinvestigatetheexpressmnofeukatTotictranslationinitiationracer4E(eIF4E)intheoccurrenceanddevelopmentofesophagealsquanlouscallcareinonla(ESCC)andthecorrelationbetweenelF4EandprognosisMethods：elf4EmRNAandproteinexpressioninesophagealearcinonlaandnormalesophagealnlueosawered

4、etectedbyreversetranscriptasepolymerasechainreaction(RT—PCR)andmethocLResults：ThelevelofelF4EmRNAexpressioninESCCwas05610079．significantlyhigherthanthatinadjacentesophagealnlueosa04420061(P<005)，thelevelsofeIF4EmRNArelativeexpressmnwereinflwencedbypathdogicalgradingofthetmnor(P=0012)，andnm

5、hiplecomparisonsshowedthattheexpressmnwoshigherinl0w—differentiatedgroupthaninwel—diferentiatedgroupfP<0051eIF4EmRNAexpressionindife~entinvasiongradewerediferent(P=0003)，andnmhiplecomparisonsshowedthathigherinfibernlenlbraneanddeepnmsclethaninnlucousler(P<005)TheI『11『11un0hlst0chstyresults

6、：thepositiveexpressmnrateofelF4Ewas7500％，significantlyhigherthaninesophagealnlueosa3080％(P=0001)TherewasapositiveCODrdationwithpathdogicalgradingofthetmnor(=0228，P<005)Therewascorrdati,mwithinvadvedepth(P<005)，butnotwithgender，age，lymphnodenletastasisanddiferentchnical~ages(P>005)5一yearsmw

7、ivalrateofpatientswithhi*ghexpressionofelF4Ewas318％．significantlybwerthanthe533％withlowexpressiongroup(P<005)TheCoxmodelanahslsshowedthattheexpressmnofelF4EinfluencedtheprognosisofESCC，soitcanbeusedassupplementat7indicatorofprognosisCondusion：eIF4Eexpressmnhad