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《《葛花枳椇子配伍对酒精性肝损伤大鼠血中乙醇浓度和肝中乙醇脱氢酶活性的量—时—效影响》.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、环球中医药2015年3月第8卷第3期GlobalTraditionalChineseMedicine,March2015,Vo1.8,No.3299·论著·葛花枳棋子配伍对酒精性肝损伤大鼠血中乙醇浓度和肝中乙醇脱氢酶活性的量一时一效影响刘明陈绍红钟赣生柳海艳赵桐【摘要】目的观察不同剂量葛花、枳棋子2:1比例配伍后解酒保肝的量一时一效关系,明确葛花枳棋子配伍使用的最佳条件。方法采用56。红星二锅头白酒灌胃复制慢性酒精性肝损伤动物模型的方法,将Wistar雄性大鼠,按体重随机分为六组:空白组,模型组,东宝肝泰对照组,葛花枳棋子2:1高剂量配伍组,葛
2、花枳棋子2:1中剂量配伍组,葛花枳棋子2:1低剂量配伍组,于实验4周、8周、12周末分别取材,腹主动脉取血,并迅速取肝左叶组织约0.2g,检测血中乙醇浓度以及肝中乙醇脱氢酶活性。结果给药8周和12周,葛花枳棋子各剂量配伍组均可降低血中乙醇浓度,增强肝中乙醇脱氢酶活性,且配伍低剂量组较其他组有一定的治疗优势。结论结果表明,不同剂量葛花、枳棋子比例配伍均有一定程度解酒保肝功效,但葛花、枳棋子2:1比例低剂量配伍效果最佳,随着给药时间的延长治疗效果越好。【关键词】葛花;枳棋子;酒精性肝损伤;乙醇浓度;乙醇脱氢酶活性【中图分类号】R285.5【文献标识
3、码】Adoi:10.3969/j.issn.1674—1749.2015.03.009Volume-when.effectinfluenceofhoveniadulcisthunbandflowerofkudzu~necompatibilitytoeth-anolconcentrationandliveralcoholdehydrogenaseactivityofexperimentalalcoholicliverdiseaseofratsHUMg。CHENShao—hong,ZHONGCan—sheng,etaLSchoolofBasicMe
4、dicalSciences,BeijingUniversityofChineseMedicine,Beng100029,ChinaCorrespondingauthor:ZHONGCan—sheng,E—mail:zhonggaasheng@souh~con【Abstract】0bjectiveToidentifythebestconditionofliverprotectionbyobservingthevolume-effectrelationshipofdifferentdosesof2:1ratiocompatibilityofhove
5、niadulcisthunbandflowerofkudzu.vineafterliquorsolution.Methods56。hongxingerguotouliquorwasusedtolavagethesixgroupstoes-tablishthechronicalcoholicliverinjuryanimalmodels.Accordingtotheweight,themaleWistarratswererandomlydividedintosixgroups:blankgroup,modelgroup,dongbaogantai
6、controlledgroup,highdosegroup.moderatedosegroupandlowdosegroupof2:1compatibilityflowerofkudzuvineandhoveniadulcisthunb.Thebloodwastakenfromabdominalaortaafter4weeks,8weeksand12weeksrespectively,then0.2gofthelefthepaticlobewasalSOtakentodetecttheconcentrationofethanolinblooda
7、ndliveralcoholdehydrogenaseactivity.ResultsAdministrationof8weeksand12weeks,differentdosesofflowerofkud-zuvineandhoveniadulcisthunbcanreducethebloodcompatibilityofethanolconcentration,enhancetheactivitiesofADHinliver.Findingsshowthatlowdosegroupoutweighsothergroupsintermsofe
8、ffica—cv.ConclusionFindingsalSOindicatethatdifferentdosesofhoveniadulcisthu
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