原发性肝细胞癌OSM、OSMR表达与临床资料关系及意义-论文.pdf

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1、84·论著·July2014，Vo1．12，No．20原发性肝细胞癌OSM、OSMR表达与临床资料关系及意义钱俊甫(平煤神马医疗集团总医院，河南平顶山467000)【摘要】目的探讨原发性肝癌(HCC)及癌旁组织中OSM、OSMR表达与临床资料的关系及意义。方法用固相夹心法酶联免疫吸附法(ELISA)检测30例HCC及其癌旁组织中OSM、OSMR表达水平，常规检测患者术前血清AFP、AST、AL丁、TBIL水平，并同时将3O例肝癌惠者按性别、年龄、Child分级、AFP、乙型肝炎表面抗原、肝硬化、TNM分期、肿瘤有无假包膜情况进行分组，通过方差分析与Logistic回归对肝癌及癌旁组织OSM、

2、OSMR表达与以上临床资料进行分析，研究原发性肝细胞癌中OSMOSMR表达与临床资料关系及意义。结果①肝癌及癌旁组织中OSM、OSMR表达与年龄、性别、乙型肝炎表面抗原阳性、Child分级、肝硬化、AST、ALT、TBIL等因素无关(P>0．05)；②肝癌及癌旁组织中OSM、OSMR表达与AFP、TNM分期、肿瘤有无假包膜相关(P<0．05)。结论OSM、OSMR与HCC发生、发展密切相关；肝癌及癌旁组织中0SM、OSMR表达与AFP、TNM分期、肿瘤无假包膜密切相关。【关键词】原发性肝细胞癌；肿瘤抑制素M；受体；临床资料；表达中图分类号：R735．7文献标识码：B文章编号：1671-819

3、4(2014)20-0084-03ExpressionandEfectsofOncostatinMandItsReceptorinHepatocellularCarcinomaTissuesandtheRelationshipbetweenClinicalDataQIANGJun(DepartmentofGenera，苫e，thePingdingshanCoalGeneralHospital,Pingdingshan467000,ChinfAbstractlObjectiveToresarechtheexpressionofoncostatinManditsreceptorinhepatoc

4、ellularcarcinomatissues，tissuessurroundinghepatomaandtherelationshipbetweenclinicaldata，toexplorepossiblelymechanismsandsignificancebywhichtheyafecthepatocellularcarcinoma．MethodsELISAimmunohistochemistryandELISAabsorbancemethodwasusedtodetecttheexpressionofoncostatinManditsreceptorinhepatocellular

5、carcinomatissuesandtissuessuroundinghepatomain30patientswithcoroborativeHCCthyoughpathology，5normallivertissueand6casestissueofHemangiomas．RoutinelytestingthelevelofAFP,AST，ALT,TBILinpatientswithpreoperativeserum，distinguishingdiferentgroupsbysex，age，Childclassification，AFP,HBsAg，livercirrhosis，TNM

6、stage，tumorpseudocapsulesituationwhetherin30casespatientswithHCC．AnalysisedtherelationshipbetweenclinicaldataandoncostatinManditsreceptorinhepatocellularcarcinomatissues，tissuessurroundinghepatomabyvarianceanalysisandLogisticregression，toresarechexpressionandefectsofoncostatinManditsreceptorinhepat

7、ocellularcarcinomatissuesandtherelationshipbetweenclinicaldata．Results①TheexpressionofOSMandOSMRinhepatocellularcarcinomatissuesandtissuessurroundinghepatomaareunrelatedwiththegroupsofsex，age，Childclassific