主观认知下降ppt课件.ppt

主观认知下降ppt课件.ppt

ID:58550174

大小:4.47 MB

页数:14页

时间:2020-09-05

主观认知下降ppt课件.ppt_第1页
主观认知下降ppt课件.ppt_第2页
主观认知下降ppt课件.ppt_第3页
主观认知下降ppt课件.ppt_第4页
主观认知下降ppt课件.ppt_第5页
资源描述:

《主观认知下降ppt课件.ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库

1、subjectivecognitivedecline主观认知下降ReferenceSunY,YangFC,LinCP,etal.BiochemicalandNeuroimagingStudiesinSubjectiveCognitiveDecline:ProgressandPerspectives.[J].CNSNeuroscience&Therapeutics,2015,21(10):768–775.1.Self-experiencedpersistentdeclineincognitiveco

2、mparedtopreviousstatue.2.Normalage-,gender-,andeducation-adjustedperformanceonstandardizedcognitivetests,whichareusedtoclassifyMCI.SCDMCImild cognitive impairmentDementia12SCDsubjectivecognitivedecline3Alzheimer’sdisease(50%-75%)DementiaaMCIaMCIischar

3、acterizedbyslightmemoryimpairmentwithrelativepreservationofothercognitivedomains.aMCIisoftenfoundtobeaprodromalstateofAD,presagingsubsequentconversiontoAD.aMCI10-15%ADannualconversionrateSCDdepressionpsychiatricconditionssubstanceabusemedicaldisorders

4、neurologicdiseasemedicationuseSubjectivedeclineinmemory,ratherthanotherdomainsofcognitionOnsetofSCDwithinthelast5yAgeatonsetofSCD≥60yConcerns(worries)associatedwithSCDFeelingofworseperformancethanothersofthesameagegroupIfavailableorpossibletoobtainint

5、herespectivestudy:ConfirmationofcognitivedeclinebyaninformantPresenceoftheAPOEε4genotypeBiomarkerevidenceforAD(definespreclinicalAD)FeaturesthatincreasethelikelihoodofpreclinicalADinindividualswithSCDaccordingtocurrentdata:SCDplus(preclinicalAD)aMCIAD

6、12SCD3CSFBiomarkersInalargerstudy,Visseretal.investigatedtheprevalenceofAD-predictingCSFprofileandcognitiveevolutioninthreegroupsofpatients:SCD,aMCI,andnonamnesticMCI.TheyfoundthattheCSFprofilesofpatientsinallthreegroupswhoshowedsubsequentcognitivedec

7、linewereconsistentwiththeAD-predictingprofiles,withtheseprofilesaremorecommoninthesegroupsthaninhealthycontrols(i.e.,lowAb42andhightaulevels).StructuralMRI1.Thedegreeofatrophyobservedwasrelatedtothemagnitudeofthepatients’self-reportedcognitivecomplain

8、ts.2.SCDpatientshadalesserlefthippocampalvolumethanhealthycontrols.3.VolumetricreductionswerefoundinSCDpatientsthatwereanalogoustochangesobservedinpatientswithaMCI,includingreductionsinmedialtemporalandfrontotemporalregions.DiffusionMRIDiffusi

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。