氨基酸all

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1、天然氨基酸属性表Residues:alaargasnaspcysgluglnglyhisileleulysmetpheproserthrtrptyrvalAtomSetARNDCEQGHILKMFPSTWYVacidic**acyclic***************aliphatic*****aromatic****basic***buried********charged*****cyclic*****hydrophobic**********large***********medium******negative**neutral*********

2、*******polar**********positive***small***surface************HydrophobicityofthePhysiologicalL-alpha-AminoAcidsfromDr.ShaunD.Black(UniversityofTexasHealthCenteratTyler)ParametersfortheUnmodifiedPhysiologicalL-alpha-AminoAcids†‡AminoAcid3-LetterCode1-LetterCodeMolecularWeightHydrop

3、hobicityAlanineAlaA89.090.616CysteineCysC121.160.680AspartateAspD133.100.028GlutamateGluE147.130.043PhenylalaninePheF165.191.00GlycineGlyG75.070.501HistidineHisH155.160.165IsoleucineIleI131.180.943LysineLysK146.190.283LeucineLeuL131.180.943MethionineMetM149.210.738AsparagineAsnN1

4、32.120.236ProlineProP115.130.711GlutamineGlnQ146.150.251ArginineArgR174.200.000SerineSerS105.090.359ThreonineTheT119.120.450ValineValV117.150.825TryptophanTrpW204.230.878TyrosineTyrY181.190.880†Themolecularweightsgivenarethoseoftheneutral,freeaminoacids;residueweightscanbeobtaine

5、dbysubtractionofoneequivalentofwater(18g/mol).‡Thehydrophobicitiesgivenarethe"Scaled"valuesfromcomputationallog(P)determinationsbythe"SmallFragmentApproach"(see,"DevelopmentofHydrophobicityParameterstoAnalyzeProteinsWhichBearPost-orCot

6、ranslationalModifications"Black,S.D.andMould,D.R.(1991)Anal.Biochem.193,72-82).Theequationusedtoscalerawlog(P)valuestothescaledvaluesgivenisasfollows:ScaledParameters=(RawParameters+2.061)/4.484.TrendofHydrophobicityParametersforthePhysiologicalL-alpha-AminoAcidsPhe&

7、gt;Leu=Ile>Tyr=Trp>Val>Met>Pro>Cys>Ala>Gly>Thr>Ser>Lys>Gln>Asn>His>Glu>Asp>Arg氨基酸一览表+-R-CH(NH3)COO等电点极性pK1'pK1'pKR'缩写名称R的结构+PI电荷CO2HNH3R基非极性A

8、Ala丙氨酸AlanineCH36.022.349.69疏水不带电+12.48NH2C(=NH2)N极性RArg精氨酸Arginine10.762.179.04亲水HCH2CH2CH2正电胍基Asparagi极性NAsn天冬酰胺NH2COCH25.412.028.80亲水ne不带电Asprarti极性3.86亲水DAsp天冬氨酸H