a tubular bioreactor for high density cultivation

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1、ATubularBioreactorforHighDensityCultivationofMicroorganismsIsaoEndo1,TeruyukiNagamune1,SusumuTachikawa2,HidekiInaba21TheInstituteofPhysicalandChemicalResearch,Wako-shi,Saitama,Japan2SumitomoHeavyIndustries,Ltd.,Hiratuka-shi,Kanagawa,Japan1Introduction.................................................

2、.................22DesignoftheTBR............................................................22.1MembraneModule.........................................................22.2ConstitutionandCharacteristicsoftheTBR...................................33ExperimentalDetails..................................

3、.........................43.1Equipment................................................................43.2Method.................................................................43.2.1TestOrganismandCompositionoftheBasalCultureMedium.............43.2.2ExperimentalConditions...................i.......

4、....................53.2.3MeasuringMethod....................................................64ResultsandDiscussion.............................;.............................64.1ComparisonofBatchCultureExperimentsObtainedwiththeTBRwiththoseoftheJarFermentor...................................9......

5、..................64.2CultivationofLactobacilluscaseiwithCross-FlowFiltrationataConstantDilutionRate.....................................................................74.3CultivationofL.caseiwithCross-FlowFiltrationbyIncreasingDilutionRate......95Conclusion.........................................

6、..........................106Nomenclature.................................................................l17References....................................................................11Bysimulatingthefunctionsoftheanimalintestine,theauthorshavedevelopedanoveltubularbioreactor(TBR)whichiscapableo

7、fcontainingboththereactionandseparationofproductsinasinglesystem.Thisreactorconsistedofinorganicultrafiltrationmembranemodulesintheprimarypartofthesystem,aheatexchangerandarecyclingpump.Theoperationch