1、电刺激隐神经对大鼠脊髓cfos基因表达的影响【关键词】cfos基因;脊髓;隐神经;躯体痛;免疫组化 Effect of Electrically Stimulating Saphenous Nerveon cfos Gene Expressionin Spinal Cord Neurons of Rats YANG Yu1,YANG Jingyu1,GUO Li2,SHANG Lihong3,CHEN Kuimin3,infan4*,HANQing5 (1.Life Science and Biopharmaceuti
2、cal College,Shenyang Pharmaceutical University,Shenyang 110015,China;2.Scientific Experimental Center of Shenyang Medical College;3.Functional Experimental Center of Shenyang Medical College;4.Department of Physiology,Shenyang Medical College;5.DepartofHygiene,PLA95979Army
3、) AbstractObjective:To observe the expression changes of the cfos gene in spinal cord neurons by somatic noxious stimulation.Methods:The electrical stimulation of saphenous nerve at different times munohistochemical technique.Results:Spinal cord Fos protein expression co
4、uld lead to a significant increase by immunohistochemical technique,noxious electrical stimulation increased significantly 30 minutes,the most significant increase 60 minutes,then fades after 120 minutes.Conclusions:This study proved the noxious electrical stimulation of s
5、aphenous nerve,the spinal Fos protein expression can lead to a significant increase,this expression is timedependent. Keyatic pain;immunohistochemistry 痛觉是一种不愉快的感觉和情绪体验,伴有实际或潜在的组织损伤。疼痛是最普遍的临床症状之一,虽然治疗方法很多,但疗效均不尽人意,给患者带来巨大痛苦,是临床治疗一大难题。脊髓后角浅表层既是接受躯体伤害性信息传递的初级门户又是对伤害性信息处理的