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时间:2020-04-20
《顺铂联合金葡素或香菇多糖治疗恶性胸腔积液导致发热的差异分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·54·JOURNALOFBASICANDCLINICALONCOLOGYVo1.26No.1Feb.2013顺铂联合金葡素或香菇多糖治疗恶性胸腔积液导致发热的差异分析王守峰,张金岭,殷忠关,李明,张云,张峰(1.山东大学附属临沂市人民医院肿瘤科,山东临沂276000;2.泰山医学院,山东泰安271000)[摘要]目的分析顺铂联合金葡素或香菇多糖胸腔内灌注治疗恶性胸腔积液导致发热差异的原因。方法将经病理证实的恶性胸腔积液患者52例随机分为2组(A组和B组),胸腔内分别灌注顺铂联合金葡素或香菇多糖,3d后2组交换灌注药物行第2次胸腔内灌注,对比观察2次患者发热
2、的情况。结果第1次胸腔内灌注后,顺铂联合金葡素发热率(56.00%)高于顺铂联合香菇多糖(11.11%)(P=0.0006);第2次胸腔内灌注后,顺铂联合金葡素发热率(55.56%)高于顺铂联合香菇多糖(32.00%),但差异无统计学意义(P=0.0875)。同组患者前后2次应用顺铂联合金葡素或香菇多糖后,A组发热率顺铂联合金葡素高于顺铂联合香菇多糖,但差异无统计学意义(P=0.0874);B组发热率顺铂联合金葡素高于顺铂联合香菇多糖(P=0.0005)。结论顺铂联合金葡素胸腔内灌注治疗恶性胸腔积液造成发热率较顺铂联合香菇多糖高,可能由于顺铂损伤胸膜上皮屏障
3、功能后金葡素中的内毒素等致热原大量入血所致。[关键词]顺铂;香菇多糖;金葡素;发热;肺癌;胸腔积液DOI:10.3969/j.issn.1673·54t2.2013.O1.020[中图分类号]R734.2[文献标识码]A[文章编号]1673—5412(2013)01—0054—03AnalysisofDiferencesofFeverCausedbyCisplatinCombinedwithStaphyl0coccinorLentinaninMalignantPleuralEfusionWangShoufeng,ZhangJinling,YinZhongme
4、i,LiMing,ZhangYun,ZhangFeng(1.DepartmentofOneology,LiPeople’SHospitalAffiliatedtoShandongUniversity,Linyi276000,China;2.TaishanMedicalCollege,Taian271000,China)[Abstract]ObjectiveToanalyzethedifferencesoffevercausedbycisplatincombinedwithstaphylococcinorlentinaninmalignantpleuralef
5、fusion.MethodsFifty—twopatientswithmalignantpleuraleffusionweredividedintogroupAandgroupB,andweregivenwithintrapleuralinfusionofcisplatinplusstaphylococcinorcisplatinpluslen—tinanrespectively.Threedayslater,thedrugsofperfusionareinterchangedbetweengroupAandgroupB.ResultsAfterthefir
6、stinfusion,thefeverrateofcisplatinplusstaphylococcin(56.00%)werehigherthanthatofcisplatinpluslentinan(11.11%)(P=0.0006);afterthesecondinfusion,thefeverrateofcisplatinplusstaphylococcin(55.56%)werehigherthanthatofcisplatinpluslentinan(32.00%),buttherewasnostatisticaldifferencebe—twe
7、enthecisplatinplusstaphylococcinandthecisplatinpluslentinan(P=0.0875).Inthesamegroupthecispla—tinplusstaphylococcinorthecisplatinpluslentinanweregivenoneafteranother,thefeverrateofcisplatinplusstaphylococcinwasstillhigherthanthatofcisplatinpluslentinaningroupA,buttherewasnostatisti
8、caldifferencebetweenthecis
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