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1、介入治疗对急性冠脉综合征患者炎症反应及血小板活性影响[摘要]目的:观察急性冠脉综合征患者冠脉介入治疗术前、术后炎症介质IL-6、hsCRP水平及血小板活性指标CD62p、CD63的改变。方法:58例急性冠脉综合征患者在冠脉介入术前30min,术后2、24、72、96h分别检测炎症介质IL-6、hs-CRP和血小板功能活性指标CD62p、CD63水平。hs-CRP测定采用乳胶增强免疫散射比浊法,IL-6测定采用双抗体夹心酶联免疫吸附法(ELISA),流式细胞仪测定CD62p、CD63水平。选择53
2、例冠状动脉造影结果正常者作对照,观察冠脉介入前后指标的变化并与对照组比较。结果:与对照组比,急性冠脉综合征组IL-6、hs-CRP、CD62p、CD63明显增高(P0.05)。结论:血小板活化和炎症反应在急性冠脉综合征发生和发展过程中起重要作用,冠脉介入治疗激活急性冠脉综合征患者血小板活性因子及炎症反应因子。�[关键词]急性冠状动脉综合征;冠脉介入治疗;炎症反应;血小板活化�[中图分类号]R541.4;R815[文献标识码]A[文章编号]1671-7562(2010)01-0040-04�doi
3、:10.3969/j.issn.1671-7562.2010.01.011��Effectofpercutaneouscoronaryinterventionon11inflammatoryreactions�andplateletactivationinpatientswithacutecoronarysyndrome��WANGYong�1,FENGYi2,ZHUYuan-sheng�1,ZHANGNeng-feng1(1.DepartmentofCardiology,HuaianHospi
4、tal,XuzhouMedicalCollege,Huaian223002,China;2.DepartmentofCardiology,ZhongdaHospital,SoutheastUniversity,Nanjing210009,China)�[Abstract]Objective:ToobservethechangesofserumlevelofinflammatorymediatorsIL-6,hsCRPandplateletactivityindexCD62p,CD63before
5、andafterpercutaneouscoronaryintervention(PCI)inpatientswithacutecoronarysyndrome(ACS).Methods:Thebloodwascollectedrespectivelyat30minbeforePCIand2,24,72,96hafterPCIin58patientswithACSandcontrolgroup.TheserumlevelsoftheCD62p,CD63wereassayedbyflowcytom
6、etry,thehs-CRPwasmeasuredbyimmunescatterturbidimetryandIL-6wasanalyzedbyenzymelinkedimmunosorbentassay(ELISA).Results:TheIL-6,hs-CRP,CD62p,11CD63levelsinthepatientswithACSincreasedsignificantlycomparedwithcontrolgroup(P0.05).Conclusion:Plateletactiva
7、tionandinflammatoryreactionsplayanimportantroleintheoccurrenceanddevelopmentofACS.PCImayactivateplateletactivationandinflammatoryreactionsfactorsinpatientswithACS.�[Keywords]acutecoronarysyndrome;percutaneouscoronaryintervention;inflammatoryreactions
8、;plateletactivation��急性冠脉综合征(acutecoronarysyndrome,ACS)主要病理改变是冠状动脉粥样硬化斑块的破裂,诱发血栓形成。经皮冠状动脉介入治疗(percutaneouscoronaryintervention,PCI)包括经皮腔内冠状动脉成形术和经皮冠状动脉支架置入术,是ACS重建冠状动脉血运的有效方法。PCI可诱导和加重冠状动脉局部炎症反应[1],对血管内皮的增生与再狭窄(restenosis,RS)起着重要作用,同时引起斑块破裂与内皮损伤,易引起急
