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1、工业生物催化技术80423（Industrialbiocatalysistechnology80423）Andpage1-----------------------May2003intestinalprocessingfirstvolumefirstphase12ChineseJournalofBioprocessEngineeringMay2003IndustrialbiocatalysistechnologyLinLin,CaoZhuan,XingXinhui,LiuZheng(Instituteofbioc
2、hemicalengineering,Departmentofchemicalengineering,TsinghuaUniversity,Beijing100084,China)Abstract:industrialbiocatalysistechnologyinengineeringapplicationofproteinenzymeasthecore,isconsideredtobefollowingthebiopharmaceuticalandbiotechnologyforplantafterthetur
3、noutsThethirdwave.Itsdevelopmentandapplicationwillbringaboutfundamentalchangesintheindustrialchemistryofmankind.TheriseofindustrialbiocatalysisandthefollowingtwoconcernsThereisacloserelationshipbetweenthetechnologicalfactors:(1)thedevelopmentofproteindirectede
4、volution,(2)thedevelopmentofgenomicsandproteomics.DiscussiononindustrialstarchThepresentsituationanddevelopmenttrendofcatalytictechnology,andsomesuggestionsonhowtodevelopthebaseandapplicationofthiscityareputforward.GuanJian'sword:Industrialbiocatalysis;Biotran
5、sformation;directedevolution;genomics;ProteomicsCLCnumber:814.2documentidentificationcode:Aarticlenumber:1672,3678(2003)01,one0012,one05IndustrialbiocatalysisLINZhang-lin,CAOZhu-an,XINGXin-hui,LIJZheng(DepartmentofChemicalEngineering,T"onyhuaUniversity,Beijing
6、100084,China)Abstract:Biocatalysis,theuseofenzymesinindustrialprocesses,isideredthethudwaveofbiotechnol-RevolOgy(afterbiomedicineandtransgenicplants).Ithasthepotentialtoutionizethetraditionalchemistry1Relatedindustries.Therapidadvanceinbiocatalysissincehate199
7、0'6hasbeendrivenfieldtwocriticalfactors:(1)newtoolsforenzymeengineeringsuchasdirectedevolution,whichmakeitpossibletotailorenzymesforIndustrialuses;and(2)thegerromicsandproteomicsresearch,whichhasprovideahugerepertoireofen-currentstatusanddevelopmenttrendsinbio
8、catalysisarereviewedinzymesaswellasnewbiosyntheticroutes.thisreport,alongwithseveralstrategicrecommendationsforthisimportantareaofr&dinchina.keywords:biocatalysis;enzymeengineering
