中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察

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1、中药六味安消联合左氧氟沙星根除幽门螺杆菌疗效观察【摘要】目的观察中药六味安消联合左氧氟沙星方案根除Hp的疗效。方法选择Hp阳性慢性胃炎250例,随机分为A组128例和B组122例,A组口服埃索美拉唑20mg加左氧氟沙星200mg,2次/d,1周,六味安消胶囊2.0g,3次/d,2周。B组口服埃索美拉唑片20mg加阿莫西林分散片1g加克拉霉素500mg,2次/d,1周。疗程结束1个月后行14C尿素呼气验检测Hp。结果A组和B组HP根除率分别为84.2%和73.0%,差异有显著性(P>0.05);A组和B组临床有效率分别为97.5%和94.8%,差异无显著性(P>0.05)。结

2、论六味安消联合左氧氟沙星疗法比传统标准三联疗法的Hp根除率高,且与传统三联临床疗效相当,可作为根除Hp的治疗方案之一。【关键词】六味安消;左氧氟沙星;幽门螺杆菌TheclinicalobservationforeradicationofHelicobacterpyloriwithtraditionalmedicineliuweianxiaoandlevofloxacinRENYi-ming,ZHUCai-hong,CHENJian-hua,etal.TheFourthClinicHospitalofYangZhou7University,DepartmentofGastro

3、enterology,NanTongRichHospital,Nantong226010,China【Abstract】ObjectiveToinvestigatetheefficacyoferadicationofHelicobacterpylori(Hpylori)withtraditionalmedicineLiuWeiAnXiaoandlevofloxacin.MethodsAtotalof250Hpyloripositivepatientssufferingfromchronicgastritiswererandomlyallocatedintotwogroups

4、.GroupA128patientsreceivedesomeprazole20mg+levofloxacin200mg,twicedailyfor1wk,LiuWeiAnXiao2g,threetimesdaily,for2wk.groupB122patientsreceivedesomeprazole20mg+amoxicillin1g+clarithromycin500mg,twicedailyfor1wk.Hpyloristatuswasassessed4weeksaftertheendoftreatmentby14Cureabreathtest.ResultsHp

5、rioreradicationrateswere84.2%ingroupAand73.0%ingroupB,respectively,andthedifferencewassignificant(P0.05).ConclusionThetherapywithLiuWeiAnXiaoandlevofloxacinhasahigherHprioreradicationratesthantraditionaltrigeminytherapy,andasamecliniceffectivetotraditionaltrigeminytherapy.itisafeasibleH7py

6、lorieradicationregimen.【Keywords】LiuWeiAnXiao;Levofloxacin;Helicobacterpylori(Hpylori)慢性胃炎、十二指肠溃疡和胃溃疡等疾病均与幽门螺杆菌(Helicobacterpylori,Hp)感染密切相关,根除Hp感染,是治疗上述疾病的关键措施之一[1]。作者应用传统中药六味安消联合左氧氟沙星根除Hp及治疗Hp阳性慢性胃炎患者,疗效可靠,兹报告如下。1资料与方法1.1病例选择标准门诊慢性胃炎患者入选条件:①胃镜检查和病理活检诊断慢性非萎缩性胃炎;②快速尿素酶试验Hp阳性;③14C-呼气试验Hp阳性;

7、④治疗前2周内未用过服抗菌药物、铋剂及抑酸剂;⑤无严重心、肝、肾等系统性疾病和消化系统肿瘤;⑥年龄大于18岁。1.2一般资料入选患者250例,随机分为A组(治疗组)和B组(对照组)。A组128例,男79例,女49例,年龄(43±17)岁(28～69岁);B组122例,男63例,女59例,年龄(44±20)岁(26～70岁)。两组病例在性别、年龄、体质量、吸烟史、饮酒史、病程和病情等方面差异均无统计学意义(P>0.05)。1.3治疗方案A组口服埃索美拉唑(无锡阿斯利康)20mg加左氧氟沙星(新昌制药)200mg,2次