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1、现代药物与临床Drugs&Clinic第29卷第4期2014年4月·363·夏黄颗粒提取浸膏粉的粉体学和稳定性研究1,2,32,32,3*1,2,3肖瑞颖，廖茂梁，张铁军，胡乔1.天津中医药大学，天津3001932.天津药物研究院释药技术与药物代谢动力学国家重点实验室，天津3001933.天津药物研究院中药现代制剂与中药质量控制技术国家和地方工程实验室，天津300193摘要：目的对夏黄颗粒提取浸膏粉进行处方前粉体学和稳定性研究，为设计优良的颗粒制剂处方提供参考。方法考察夏黄颗粒提取浸膏粉的主要粉体学参数，如堆密度、休止
2、角、溶化性、pH值、吸湿性、临界相对湿度。以主要活性成分芦荟苷为指标，考察高温、高湿和强光照射的影响。结果夏黄颗粒提取浸膏粉流动性较差，休止角大于45°，水溶性较好，呈弱酸性，临界相对湿度为72%；不耐高温，易吸湿，不耐光照。结论夏黄颗粒提取浸膏粉应在密封、避光、干燥处储存。关键词：夏黄颗粒提取浸膏粉；粉体学；稳定性中图分类号：R283.6文献标志码：A文章编号：1674-5515(2014)04-0363-04DOI:10.7501/j.issn.1674-5515.2014.04.008Micromeritican
3、dstabilitystudiesonXiahuangGranuleextracts1,2,32,32,31,2,3XIAORui-ying,LIAOMao-liang,ZHANGTie-jun,HUQiao1.TianjinUniversityofTraditionalChineseMedicine,Tianjin300193,China2.StateKeyLaboratoryofDrugDeliveryTechnologiesandDrugMetabolism,TianjinInstituteofPharmaceu
4、ticalResearch,Tianjin300193,China3.TheNationalandLocalEngineeringLaboratoryoftheModernizedChineseMedicineandChineseMedicineQualityControlTechniques,TianjinInstituteofPharmaceuticalResearch,Tianjin300193,ChinaAbstract:ObjectiveToevaluatethepreformulationstudies,s
5、uchasmicromeriticandstabilitystudiesonXiahuangGranuleextractsandtoprovideareferenceforthedesignoffineparticleformulationofdesign.MethodsPowdermicromeriticsmajorparametersofXiahuangGranuleextracts,suchasbulkdensity,angleofrepose,dissolveresistance,pHvalue,moistur
6、eabsorption,andcriticalrelativehumiditywerestudied.Aloinasthemainactiveingredientintheprescriptionwasdeterminedtocomparetheeffectsofhightemperature,highhumidity,andstronglightonXiahuangGranuleextract,suchasbulkdensity,angleofrepose,dissolveresistance,pHvalue,moi
7、stureabsorption,andcriticalrelativehumiditywerestudied.ResultsXiahuangGranuleextractshadthegoodwatersolubilitywithreposeanglegreaterthan45degrees,butpoormobilityandweakacidity.Thecriticalrelativemoistureofitwas72%.XiahuangGranuleextractshadnotbeenresistanttohigh
8、temperature,moistureabsorption,andlightfastproperties.ConclusionThepowderofXiahuangGranuleextractsshouldbestoreduponsealed,dark,anddryplace.Keywords:XiahuangGranuleex
