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1、“专业储备人才”笔试试卷深圳市康哲药业有限公司适用范围：校园招聘研究生群体文件编号：hr-zp-010版本：1.0专业储备人才笔试试卷V.1.0一．英译中：（现场测试：20分钟）UrsodeoxycholicAcidinCholestaticLiverDisease:MechanismsofActionandTherapeuticUseRevisitedUrsodeoxycholicacid(UDCA)isincreasinglyusedforthetreatmentofcholestaticliverdiseases.Experime
2、ntalevidencesuggeststhreemajormechanismsofaction:(1)protectionofcholangiocytesagainstcytotoxicityofhydrophobicbileacids,resultingfrommodulationofthecompositionofmixedphospholipid-richmicelles,reductionofbileacidcytotoxicityofbileand,possibly,decreaseoftheconcentrationofh
3、ydrophobicbileacidsinthecholangiocytes;(2)••••••(3)protectionofhepatocytesagainstbileacid–inducedapoptosis,involvinginhibitionofmitochondrialmembranepermeabilitytransition(MMPT),andpossibly,stimulationofasurvivalpathway.Inprimarybiliarycirrhosis,UDCA(13-15mg/kg/d)improve
4、sserumliverchemistries,maydelaydiseaseprogressiontoseverefibrosisorcirrhosis,andmayprolongtransplant-freesurvival.Inprimarysclerosingcholangitis,UDCA(13-20mg/kg/d)improvesserumliverchemistriesandsurrogatemarkersofprognosis,buteffectsondiseaseprogressionmustbefurtherevalu
5、ated.AnticholestaticeffectsofUDCAhavealsobeenreportedinintrahepaticcholestasisofpregnancy,liverdiseaseofcysticfibrosis,progressivefamilialintrahepaticcholestasis,andchronicgraft-versus-hostdisease.FutureeffortswillfocusondefinitionofadditionalclinicalusesofUDCA,onoptimiz
6、eddosageregimens,aswellasonfurtherelucidationofmechanismsofactionofUDCAatthemolecularlevel.(HEPATOLOGY2002;36:525-531.)斜体字体部分的注解：ursodeoxycholicacid熊去氧胆酸cholestatic胆汁淤积性cholangiocytes胆管细胞hydrophobic疏水性phospholipids磷脂canalicular微管apoptosis（细胞）凋亡mitochondrial线粒体的surrogate替
7、代品graft-versus-host移植物抗宿主primarysclerosingcholangitis原发性硬化性胆管炎“专业储备人才”笔试试卷深圳市康哲药业有限公司适用范围：校园招聘研究生群体文件编号：hr-zp-010版本：1.0二．简答题：（限期内邮件回复答卷，建议每题在1000字内）I．基于目前你对处方药营销推广模式和运作的理解，从推广理念、推广模式、推广手段、以及核心竞争优势等方面，阐述处方药“专业化学术推广”和“商业手段推广（即带金销售）”之主要区别；II．在处方药领域成为一名合格的从事“专业化学术推广”工作的推广经理，
8、需要具备哪些必备胜任素质（可提出五项）？为什么？三．论述题：（限期内邮件回复答卷，建议每题在2000字内）“优思弗”是康哲药业多年独家代理推广的肝科治疗用药，请根据你对药品推广市场策划的理解和能够查询收集到
