A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.[2017][Cell][10.1016j.cell.2017.05.018]

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1、ArticleAUniqueMicrogliaTypeAssociatedwithRestrictingDevelopmentofAlzheimer’sDiseaseGraphicalAbstractAuthorsHadasKeren-Shaul,AmitSpinrad,AssafWeiner,...,MarcoColonna,MichalSchwartz,IdoAmitCorrespondenceassaf.weiner@weizmann.ac.il(A.W.),michal.schwartz@weizmann.ac.il(M.S.),ido.amit@weizmann.ac.il(I

2、.A.)InBriefAnewtypeofmicrogliaassociatedwithrestrictingneurodegenerationmayhaveimportantimplicationsfortreatmentofAlzheimersandrelateddiseases.HighlightsdSingle-cellRNA-seqinAlzheimersmodelidentifiedanovelmicrogliatype(DAM)dDAMareAlzheimersdisease-associatedphagocyticcellsconservedinmiceandhumandD

3、AMareactivatedsequentiallybyTrem2-independentand-dependentpathwaysdDAMactivationrequiresdownregulationofmicrogliainhibitory-checkpointpathwaysKeren-Shauletal.,2017,Cell169,12761290June15,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.05.018ArticleAUniqueMicrogliaTypeAssociatedwithRest

4、rictingDevelopmentofAlzheimer’sDiseaseHadasKeren-Shaul,1,6AmitSpinrad,1,2,6AssafWeiner,1,3,6,*OritMatcovitch-Natan,1,2,6RazDvir-Szternfeld,2TylerK.Ulland,4EyalDavid,1KutiBaruch,2DavidLara-Astaiso,1BeataToth,5ShalevItzkovitz,5MarcoColonna,4MichalSchwartz,2,7,*andIdoAmit1,7,8,*1DepartmentofImmunolo

5、gy,WeizmannInstituteofScience,Rehovot7610001,Israel2DepartmentofNeurobiology,WeizmannInstituteofScience,Rehovot7610001,Israel3HubrechtInstitute-KNAW(RoyalNetherlandsAcademyofArtsandSciences),andUniversityMedicalCenter,CancerGenomicsNetherlands,3584CGUtrecht,theNetherlands4DepartmentofPathologyand

6、Immunology,WashingtonUniversitySchoolofMedicine,St.Louis,MO63110,USA5DepartmentofMolecularCellBiology,WeizmannInstituteofScience,Rehovot7610001,Israel6Theseauthorscontributedequally7Seniorauthor8LeadContact*Correspondence:assaf.weiner@weizmann.ac.il(A.W.),michal.schwartz@weizmann.ac.il(M.S.),ido.

7、amit@weizmann.ac.il(I.A.)http://dx.doi.org/10.1016/j.cell.2017.05.018SUMMARYetal.,2011;Zivetal.,2006).Inthemouseembryo,microgliamigratefromtheyolksactotheCNSatembryonicdays8–9,un-Alzheimersdisease(AD)isadetrimentalneur