2型糖尿病并发视网膜病变患者血清脂联素和超敏c反应蛋白浓度的变化

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1、2型糖尿病并发视网膜病变患者血清脂联素和超敏C反应蛋白浓度的变化【摘要】目的：探讨2型糖尿病并发视网膜病变(diabeticretinopathy,DR)患者血清脂联素和超敏C反应蛋白(highsensitivityCreactiveprotein，hsCRP)浓度的变化。方法：病例对照研究。采用酶联免疫吸附法和速率散射比浊法检测49例非糖尿病视网膜病变(NDR)的糖尿病患者，46例非增生性糖尿病视网膜病变(NPDR)组患者，41例增生性糖尿病视网膜病变(PDR)组患者以及45例对照组受检者血清脂联素和超敏C反应蛋白

2、(hsCRP)浓度的变化，采用单因素设计的定量资料的方差分析，多个均数之间两两比较采用q检验，相关分析采用直线相关分析。结果：NDR组患者血清脂联素浓度8.76±3.61mg/L，hsCRP浓度3.12±1.24mg/L;NPDR组患者血清脂联素浓度6.22±2.53mg/L，hsCRP浓度4.89±1.66mg/L;PDR组患者血清脂联素浓度3.98±1.86mg/L，hsCRP浓度6.95±2.59mg/L;对照组血清脂联素浓度13.55±5.87mg/L，hsCRP浓度2.01±0.85mg/L。正常对照组与N

3、DR组、NDR组与NPDR组、NPDR组与PDR组的血清脂联素比较，差异有统计学意义(q=5.4401,P=0.000;q=3.1535,P=0.002;q=4.8756,P=0.000)。正常对照组与NDR组、NDR组与NPDR组、NPDR组与PDR组血清hsCRP浓度比较，差异具有统计学意义(q=2.4367,P=0.0017;q=2.0572,P=0.003;q=2.6184,P=0.001)。DR患者血清hsCRP与血清脂联素水平呈负相关(r=100.643,P<0.01)。结论：DR患者血清脂联素浓度水平

4、与血清hsCRP浓度水平存在显著负相关，血清脂联素浓度水平下降，伴随着血清hsCRP浓度水平的升高，且与糖尿病视网膜病变的严重程度相关。【关键词】糖尿病视网膜病变;脂联素;超敏C反应蛋白　　Abstract　　AIM:Toexplorethechangesoftheconcentrationofserumadiponectin(APN)andhighsensitivityCreactiveprotein(hsCRP)intype2diabetesmellituspatientswithdiabeticretinop

5、athy(DR).　　METHODS:TheconcentrationofserumAPNandhsCRPin49noDR(NDR)patientsweredeterminedbyELISAandratenephelometryandcomparedwiththosein46noPDR(NPDR)patients,41proliferativediabeticretinopathy(PDR)patientsand45controls.DatawereevaluatedusinganalysisofSPSSversion

6、11.0.Resultswereexpressedasmeansstandarddeviationofthemean.StatisticalcomparisonswereperformedbyOnewayanalysisofvarianceandthemeanscomparedeachotherusingqtest.10　　RESULTS:TheserumAPNandhsCRPinNDRpatientswere8.76±3.61mg/L,3.12±1.24mg/L;inNPDRpatientswere6.22±2.53m

7、g/L,4.89±1.66mg/L;inPDRpatientswere3.98±1.86mg/L,6.95±2.59mg/Landincontrolswere13.55±5.87mg/L,2.01±0.85mg/L.ThereweresignificantdifferencesinserumAPNandhsCRPbetweencontrolsandNDRpatients,NDRandNPDRpatientsNPDRandPDRpatients(q=5.4401,P=0.000;q=2.4367,P=0.0017.q=3.15

8、35,P=0.002;q=2.0572,P=0.003.q=4.8756,P=0.000;q=2.6184,P=0.001).TherewassignificantnegativecorrelationbetweenserumAPNandhsCRPinDRpatients(