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1、常用软膏剂的制备 0542327仝贇 Preparationofointments Ointmentsaresemi-solidpreparationsmadeofmedicamentsandsuitablebases,whichareintendedforexternalapplicationtotheskin.Ointmentbasesrecogni
2、zedforuseasvehiclesdistinguishedintothreegeneralclasses:theoleaginousbases,theemulsionbases,andthewater–solublebases. Therearethreegeneralmethods:themethodofgrindingandmixing,themethodofmeltingandmixing,themethodofemulsification. Ophthalmicointmentsareoin
3、tmentsforapplicationtotheeyewhosebasesgeneralincludeliquidparaffin,Vaselineandwoolfat.Specialprecautionsmustbetakeninthepreparationofophthalmicointments.Theyaremanufacturedfromsterilizedingredientsunderrigidlyasepticconditions.Theointmentbasethatisselectedmus
4、tbewithoutanyirritationtoeye. Equipments:evaporating,waterbath,electricfurnace,analyticalbalance,thermometer,microscopeetc. Materials:Stearicacid,glycerolmonostearate,Vaseline,glycerol,liquidparaffin,triethanolamine,calciumhydroxide,CMC-Na,span80,nonoxynol-10
5、,distilledwateretc.Procedures: 1. O/Wemulsionbase FormulationStearicacid 4.8gGlycerolmonostearate 1.4gLiquidparaffin 2.4gVaseline 0.4g TokeepwaterWoolfat 2.0gTriethanolamine 0.16gDistilledwat
6、eraddupto 40.0g Preparation: Addstearicacid,glycerolmonostearate,liquidparaffin,Vaselineandwoolfatintoevaporatingdish,whichthemixtureisusedasoilphase.Addtriethanolamineanddistilledwaterintobeaker,whichthesolutionisusedasawaterphase.Thetwocontainersareheate
7、dto80°Cinwaterbathandkeptuntilmeltingcompletely.Pouroilphaseintowaterphaseslowly,andstirthemfully.Coolatroomtemperature,thentheO/Wemulsionbasecanbegot.2. W/Oemulsionbase Formulation:Glycerolmonostearate 0.85gBeeswax 5.25gParaf
8、fin 3.75gStearicacid 0.625gLiquidparaffin 20.5gVaseline 3.35g TokeepwaterSpan80
