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1、SPONSOR’SFOREWORD‘Race’andthehumangenome[ThissupplementhasitsoriginsonMay15,2003,whentheIf‘race’asaconceptisoversimplified,whatcanorshouldweNationalHumanGenomeCenteratHowardUniversityheldausetodescribeanddefineourheritageorfamiliallineage?smallbutimportantworkshopinWash
2、ingtonDC.Thework-Ethnicity,genetics,ancestry,lineageandfamilyalldenoteshop,HumanGenomeVariationand‘Race’,andthisspecialsomethingaboutourorigins,butwhat?PerhapsthemoreissueofNatureGeneticswereproposedbyscientistsatHowardimmediatequestioniswhetherthecompletedHumanGenomeUn
3、iversityandfinanciallysupportedbytheGenomeProgramsProjectwilldefineaconceptofracethatisscientificallycredibleoftheUSDepartmentofEnergy,throughitsOfficeofScience;anduseful.Canamorethoroughlookatthegeneticcomple-theIrvingHarrisFoundation;theNationalInstitutesofHealth,ment
4、,theactualDNAsequencesweeachcarry,clarifyandhttp://www.nature.com/naturegeneticsthroughtheNationalHumanGenomeResearchInstitute;andinformourhistoryandrelationships?Atthesimplestlevel,eachHowardUniversity.AssummarizedbyFrancisCollins,directorofuscarriesasetofgenesthataffe
5、ctsthecolorofhisorherskinoftheNationalHumanGenomeResearchInstitute,thework-(oftenasurrogateforrace).Theexactnumberofthesegenesshopfocusedonseveralkeyquestions:“Whatdoesthecurrentisn’tknown(PLoSBiology1,19–22;2003),buttheyrepresentbodyofscientificinformationsayabouttheco
6、nnectionsonlyasmallfractionoftheestimated30,000totalgenesinouramongrace,ethnicity,geneticsandhealth?Whatremainsgenomes(Nature409,860–921;2001;andScience291,unknown?Whatadditionalresearchisneeded?Howcanthis1304–1351;2001).Wearegeneticallyfarmorenuancedandinformationbeapp
7、liedtobenefithumanhealth?Howmightvariablethanisreflectedinjustskincoloration.Withmorethisinformationbeappliedinnonmedicalsettings?Howcandata,canwebuildacomprehensiveunderstandingofourselves,weadoptpoliciesthatwillachievebeneficialsocietalout-backedbysocietalstricturesth
8、atencouragethebeneficentusecomes?”Thissupplement,supportedbytheDepartmentofoftheresultingknowledgeratherthanan
