清热化滞颗粒治疗小儿积滞兼风热证905例临床观察.doc

《清热化滞颗粒治疗小儿积滞兼风热证905例临床观察.doc》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、清热化滞颗粒治疗小儿积滞兼风热证905例临床观察作者：刘建忠,刘书堂,肖明中,汪受传,赵霞【摘要】目的观察清热化滞颗粒治疗小儿积滞兼风热证的临床疗效和对动物实验的胃肠激素影响。方法临床观察将患儿905例随机分为观察组和对照组，观察组口服清热化滞颗粒，对照组口服健儿清解液；动物实验用食积小鼠模型对胃肠相关激素进行研究。结果多期临床试验研究显示清热化滞颗粒的痊愈率和显效率分别为63.31％，23.79％，总有效率为87.10％；健儿清解液的痊愈和显效率分别为46.07％，28.57％，总有效率为74.64％。清热化滞颗粒治疗小儿积

2、滞兼风热证综合疗效，痊愈率和总有效率均优于对照组，差异有统计学意义。动物实验结果显示，清热化滞颗粒能提高小鼠血和小肠组织中胃动素、胃泌素含量，降低生长抑素水平，但对血管活性肠肽作用不明显。结论清热化滞颗粒治疗小儿积滞兼风热证疗效安全、可靠，并且有促进胃肠蠕动的作用。【关键词】清热化滞颗粒/治疗应用；积滞/中医药疗法；儿童；辨证论治；证侯【Abstract】ObjectiveToobservetheclinicalefficacyofQingreHuazhigranuletocurethechildrenretentionoff

3、oodbelongingtowindheatsyndrome，andinvestigateitseffectsonthelevelofanimalsgastrointestinalhormones.MethodsTotally905casesofretentionoffoodwererandomlydividedintoobservationgroupandthecontrolgroupinclinicalresearch.ThechildrenofobservationgrouporallytooktheQingreHua

4、zhigranule；thechildrenofcontrolgrouporallytookJianerQingjieliquid.Thegastrointestinalhormonesofdyspepticdiseasemicewereresearchedinanimalexperiment.ResultsManyclinicalstudieshadshownthattherateofcure,therateofsignificanceandthetotaleffectiverateofQingreHuazhigranule

5、was63.31%,23.79%and87.10%，respectively.Therateofcure,therateofsignificanceandthetotaleffectiverateofJianerQingjieliquidwas46.07%,28.57%and74.64%，respectively.Thecomprehensiveefficacy,curerateandtotaleffectiverateintheobservationgroupwerebetterthanthoseofthecontrolgr

6、oup,whichhadsignificantdifferencesinstatistics.Animalexperimentsshowedthatparticlescouldimprovethecontentofmotilin(MOT)andgastrin(GAS)inbloodandsmallintestinetissueofmice,andcouldreducethelevelofsomatostatin(SS),buttheeffectonvasoactiveintestinalpeptidewasnotobvious

7、.ConclusionInourstudy,theQingreHuazhigranule'sclinicalefficacyissafeandreliable，andcanobviouslyimprovethegastrointestinalperistalsisofthechildrenretentionoffood5belongingtowindheatsyndrome.【Keywords】QingreHuazhigranule/Therapeuticuse;Retentionoffood/Chinesemedicalt

8、herapy;Children;Treatmentbasedondifferentiationofsymptomcomplex;Symptomcomplex积滞，是近来儿科临床常见、多发病，且与多种疾病的发病有关，究其病因，中医认为，主要与饮食不节，喂养不当有关。小儿积滞