转化生长因子β1与椎间盘退变的相关研究

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1、万方数据中国组织工程研究与临床康复第j2卷勇享20j努2008—05—13出版JournalofClinicalRehabilitative豇ssueEngineeringResearchMayl3,2008V01．12，No20炙死爱综述转化生长因子B1与椎间盘退变的相关研究☆许建文“2，熊昌源Correlationbetweentransforminggrowth1．actorbeta1andintervertebraldiscdegenerationXuJian．wenl一。XiongChang—yuanlAbstra

2、ctBACKGRoUND：TransforminggrowthfactorB1(TGF—B1)isoneoftheimportantregulatorysubstancesforproteoglycanandcollagenmetabolisminintervertebraldiscextracellularmatrix．Itmayplayaroleinlumbarintervertebraldiscdegeneration．0BJECTIVE：ToexplorethestructuralcharacteristicsTGF

3、．131andevaluateitseffectinintervertebraldiscdegenerationandgenetherapy．RETRIEVALSTRATEGY：ChineserelatedarticlesweresearchedbycomputerinVIPandTshinghuaDatabasepublishedbetweellJanuary1995andOctober2007withthekewords”intervertebral，transforminggrowthfactorp1，traditio

4、nalChiflesemedicine”i11Chinese．Meanwhile．wesearchedMedlinefortheEnglishrelatedarticlesdatedfromJanuary1995toOctober2007with山esamekeywordsinEnglish．ArticlesaboutthestructureandothercharacteristicsofTGF-13lgene．andassociationofTGF—Blwitllintervertebraldiscdegeneratio

5、nandtraditionalChinesemedicinewereselected．Reviewarticles，repetitivestudiesandMetaanalysisarticleswereexcluded．LITERATUREEVALUATIoN：398articleswell'efirstlycollected．and37ofthemmettIleinclusivecriteria,whichmainlyintroducedtIlegenecharacteristicsofTGF-B1．effectofTG

6、F—Blonintervertebraldisccells，TGF一13lrelatedgenetherapyforintervertebraldiscdegeneration．andeffectoftraditionalChinesemedicineonTGF-131expression．DATASYNTHESIS：TGfLBlplaysakeyroleintherepairoftheinjuredcellsofnucleuspulposusinearlydegeneratedintervertebraldiscbyact

7、ivatingcellsandstimulatingcollagenexpression．SomeChinesedrugscanpromotetheexpressionofTGF—Blinintervertebraldisccellsbuttheconcretemechanismisstil】notclear．ItisfeasiblethatTGF-BlreversesintervertebraldiscdegenerationdiseasesthroughgenetherapyfbrtIleexperimentalanim

8、alstudy．However。thesafetyandefficacyofTGF—B1iniectioninhumanintervertebraldiscneedsfurtherstudy．CoNCLUSIoN：111estructureandgenelocalizationofTGF-