实验性近视眼后极部巩膜胶原和蛋白多糖水平的改变

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1、万方数据InternationalJournalofOphthalmology,V01．6,No．3．Jun．2006Teh029-82245172Email：IJO．2000@163．com、】l嘲唧Uo．魏·实验研究·实验性近视眼后极部巩膜胶原和蛋白多糖水平的改变谭佳，刘双珍，邓志宏，魏欣，谭星平ChangesofcollagenanddecorinlevelintheposteriorscleraoftheexperimentalmyopiaJiaTan，Shuang-ZhenLiu，Zhi-HongDeng，XinWei，Xing-PingTanDepartme

2、ntofOphthalmology．XiangyaHospitalofCentralSouthU-niversity。Changsha410∞8。HIln盎][1Province，ChinaCorrespondenceto：Shuan譬一ZhenLiu．DepartmentofOphthalmolo—gY，XiangyaHospitalofCentralSouthUniversity，Changsha410008，HunanProvince．China．1iushzhxy@163．comReceived：2貘撼—03一llAccepted：2麓6尚4—25Abstrac

3、t‘A王M：blnvestigatethechangesofcollagenanddecodnlevelintheposteriorscleraofGuineaPig钟esinducedbyform—deprivationandtheirassociationwiththepathogenesisofmammalmyopia。·M日拜CIDS：TwogroupsOfGuineaPigs,with10animalseach，wereincludedinthestudy．Animalsinthemonocu-lar-deprived(HD)groupweresubjecte

4、dto2wkofformdepri-vaUon，andthoseintheMD／recoverygroupweretreatedthesamewayfollowedbylwkofrecovery。两m’deprivationbymonoculareyeshadewasintroducedbetween2and3wkofageinalIanimals。Thecontralateral，untreatedeyesoftheanimalsservedasInterocularcontrols。Therefractionandtheaxialeyelenothofallanim

5、alsweremeasuredatthebegin-ningandtheendofthetreatmentperiod．AIIanimalswereSacnficedandeyesenucleatedattheendofstudy。Thepos-teriorsclerawasdissectedfromtheeyeandtheexpressionsofdecorincoreproteinmRNAandcollagenlmRNAwereas-sayedby附卜PCR。ThedatawasanalyzedbymeansofpaIiredt-testandanalysisofv

6、ariance(ANOVA)。。RESULTS：ThereweresignificantdifferencesintherelativelevelofcollagenIanddecorincoreproteinmRNAbetweentheMDeyesandinterocularcontrols(P<0．0s)whichwereal-soseenbetweentherecoveredeyesandinterocularcontrols。。CONCLUSION：CollagenIanddecorinlevelintheposteriorscleraofGuineaPigey

7、esdecreasesignificantlyuponformde。pnvation，andcanberestoredbyrecovery。Itissuggestedthat囊eybothmightbeinvolvedinthepathogenesisofmpopia．作者单位：(410008)中国湖南省长沙市，中南大学湘雅医院跟科终者笾分：谭佳，女，在读薄±研究生，磅究方囊：矮燕、斜巍及弱视。通讯作者：刘双珍．1iushzhxy@163．com收藕t3期：2006-03一ll修回日期：2006—04—25’KEYWORDS：Guinea