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1、神经退行性疾病干细胞移植治疗：目前研究现状与未来展望StemCellSourcesforTreatmentofNeurologicalDiseases(AD,PD,ALS,MS,Stroke,SCI)FabinHan,etal,JournalofNeurorestoratology2015:31–12胎儿神经干细胞治疗帕金森氏病临床研究发展历程EvansJR,MasonSL,BarkerRA.ProgBrainRes.2012;200:169-98LindvallO,etal，NatMed.2008Ma
2、y;14(5):501-3THSynucleinOverlayTransplantedfetalmesencephalicdopaminergicneurons(11-16years)developedalpha-synuclein-positiveLewybodiesingraftedneuronsSynuclein-HostUbiquintin-HostSynuclein-GraftedNeuronsUbiquintin-GraftedNeuronsGraftednigralneuronsweref
3、oundtohaveLewybody-likeinclusions14yearsaftertransplantationintothestriatumofanindividualwithPDOlanowCW.etalNatMed.2008May;14(5):504-6.TransplanteddopamineneuronsinpeoplewithPDdonotcontainLewybodiesMendez,Isacsonetal,,NATUREMEDICINEVOLUME14(5):507-509,20
4、08FreedCR,JNuclMed.2010Jan;51(1):7-15-LongtermStudy-33oftheoriginaltrialparticipantswhowerefollowedfor2yearsaftertransplantationand15ofthesesubjectswhowerefollowedfor2additionalyears.-Theseresultssuggestthatclinicalbenefitandgraftviabilityaresustainedupt
5、o4yaftertransplantation.FreedCR,Neurotherapeutics(2011)8:549–561人体胚胎干细胞分化的多巴胺神经元移植改善小鼠，大鼠和猴子帕金森氏病的运动障碍22/29DECEMBER2011
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7、NATURE
8、547，LorenzStuder，etalMemorialSloan-KetteringCancerCenterImprovedCellTherapyProtocolforParkinson’sDiseaseBasedonDifferent
9、iationEfficiencyandSafetyofhESC-,HipscandNon-HumanPrimateiPSC-DerivedDANeuronsIsacsonetal,,StemCells.2013;31(8):1548-62.DopaminereleasefromtransplantedneuralstemcellsinParkinsonianratstriatuminvivo.Zhouz,etal,ProcNatlAcadSciUSA.2014Nov4;111(44):15804-9iP
10、SC-DerivedDopamineNeuronsfunctionafterTransplantationinaNon-HumanPrimateModelofParkinson’sDiseaseCellStemCell.2015Mar5;16(3):269-74.OleIsacsonetal，HarvardStemCellInstituteStemcell-basedClinicalTrialsfor(ALS)Nuralstem,Inc.thefirstPhaseIclinicaltrialforast
11、emcell-basedtreatmentofALS.Initiatedin2010andcompletedin2013,involvedthetransplan-tationofhumanspinalcord-derivedNSCsintothespinalcordof15latetomid-stageALSpatientsGlass,Feldman,E.L.,2012.Lumbarintraspinalinjectionofneural
