超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）

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1、CorrelationofCarotidPlaqueNeovascularizationDetectedbyContrast-EnhancedUltrasoundImagingWithClinicalSymptomsYou-BinDeng,MD,邓又斌TongjiHospital,HuazhongUniversityofScienceandTechnology,Wuhan,China武汉同济医院Mechanismsofvesselwallneovascularizationinatheroscler

2、osisDoyleBetal.JACC2007;49:2073Possiblerolesformicrovesselsindiseaseprogressionincludethesupplyofcellularandsolublelesioncomponents,enhancementofintraplaquegasexchange,anddeliveryofmetabolicsubstratestotheplaquecore.DoyleBetal.JACC2007;49:2073Neovascul

3、arizationinStableandUnstableCoronaryPlaquesKolodgieFDetal.JACC2007;49:2093PlaqueneovascularizationandclinicalsymptomsFleinerMetal.Circulation2004;110:2843Numberofmicrovesselsidentifiedfromplaquesofsymptomaticandasymptomaticpatients.McCarthyMJetal.JVasc

4、Surg1999;30:261VesselDensityatHistologyAccordingtoPlaqueContrast-AgentEnhancementColiSetal.JACC2008;52:223VulnerablepatientshavevulnerableplaquesPlaqueneovascularizationistheremarkablyconsistentfeatureofvulnerableplaqueincerebrovascularpatientsContrast

5、-enhancedcarotidultrasoundimagingispromisingandmayservetodetecttheneovascularizationwithintheatheroscleroticplaqueinvivo.Carotidplaquecontrast-agentenhancementwithsonographicagentcorrelateswithhistologicaldensityofneovesselswithinthecarotidplaqueTheass

6、ociationbetweenthecarotidplaqueenhancementwithcontrastagentmicrobubblesandclinicalsymptomsisnotfullyunderstood.StudyPopulation研究方法GELog9超声诊断仪9L探头：频率为6MHz机械指数：0.13104例患者快速静脉注射SonoVue1.5ml实时观察颈动脉腔及斑块内造影剂显影情况Grade1:noenhancementwithintheplaqueorenhancemen

7、tconfinedtoplaqueadventitialsideand/orshoulderGrade2:enhancementreachingplaquecore/orextensivecontrastagentenhancementthroughouttheplaque.GradingofContrast-AgentEnhancementbyVisualInterpretationGradingofContrast-AgentEnhancementbyQuantitativeAnalysisEn

8、hancedintensityintheplaqueRatiooftheenhancedintensityintheplaquetothatinthecarotidarterylumenReceiverOperatingCharacteristicCurveAnalysisThesensitivityandspecificityforenhancedintensityintheplaque(cutoffvalue:10.0dB)were74%and62%,respec