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1、2009ASCO结肠癌进展南昌大学第一附属医院肿瘤科黎军和分子指标预测Ⅱ期结肠癌高危复发大型研究结果Ceteximab疗效的预测结肠癌辅助化疗终点Oxaliplatin相关synchronousstageIVcolorectalcancer化疗策略和方案的调整其它分子指标预测结肠癌高危复发及指导化疗Abr4000高通量Abr4001MSIAbr4002Abr401218qLOHBackground:NSABPC-01/C-02、CCF、C-04、C-0648genessignificantlyassocia
2、tedwithrecurrenceriskand66genespredictiveof5FU/LVbenefit.Multivariateanalysisyielded18genes(7prognosticgenes,6predictivegenes,5referencegenes)andseparateprognosticrecurrencescore(RS)andpredictivetreatmentscore(TS)algorithms.Methods:Geneexpressionwasquantit
3、atedbyRT-PCR.Recurrence-freeinterval(RFI),disease-freesurvival(DFS),andoverallsurvival(OS)wereanalyzedusingCoxregressionResults:IntheQUASARvalidationstudytheRSpredictedrecurrencerisk(p=0.004).TheRSalsopredictedDFS(p=0.01)andOS(p=0.04).Recurrenceriskincreas
4、edmonotonicallywithincreasingRS.Inmultivariateanalyses,RSretainedprognosticsignificance(p=0.008)independentofmismatchrepair(MMR),Tstage,nodesexamined,grade,andlymphovascularinvasion.MMRdeficiency(p<0.001)andT4stage(p=0.005).However,TSwasnotvalidatedasapred
5、ictorof5FU/LVbenefitConclusions:RSisavalidated,independentpredictorofindividualizedrecurrenceriskforstageIIcoloncancerKerretl.2009ASCOAbstractNo:4000ToinvestigatetheincidenceofMSI-HinstageII(n=395)andstageIII(n=859)COC,itsassociationwithhistopathologicalva
6、riablesanditsprognosticandpredictiveimpact。Patients：PETACC3-EORTC40993-SAKK60/00trialResults：MSIHwaspresentin22%(85)ofStageIIand12%(103)ofStageIIIcoloncancer.MicrosatelliteinstabilityisastrongprognosticfactorforRFSandOSwhenconsideringStageIIandStageIIICOC.
7、SubgroupanalysissuggestsastrongereffectinStageIIthaninStageIII.ThereisnoevidenceforaneffectoftheadditionofIRI.Tejparetl.2009ASCOAbstractNo:4001Object:TocomparetheincidenceofmolecularmarkersinstageII(SII)andIII(SIII)coloncancerandtestedtheirprognosticvaluep
8、erstage1564Patients：PETACC3-EORTC40993-SAKK60/00trialP53,SMAD4,thymidylatesynthetase(TS)andhTERT,mutationsofKRASandBRAF,microsatelliteinstability(MSI)and18qLOHResultsConclusions:Molecularmarkersincoloncancerh
