免疫球蛋白的同种型和同种异型课件

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1、Immunoglobulin:Isotypes,AllotypesandIdiotypesImmunoglobulinIsotypesDefinition-AntigenicdeterminantsthatcharacterizetheclassesandsubclassesofheavychainsandtypesandsubtypesoflightchainsHumanIgMantiserumReactswithIgM,IgG,IgA,IgD,IgEReactwithIgG,IgA,IgDan

2、dIgEAbsorbedantiserumReactsonlywithIgMRecognizesdeterminantsspecificforheavychains(isotypes)ImmunoglobulinIsotypes??????ImmunoglobulinIsotypesOccurrenceImportanceIglevelsBcelltumorsImmunodeficienciesDefinitionLocationIgM(kappa)IgG1(kappa)Immunoglobuli

3、nAllotypesDefinition-AntigenicdeterminantsspecifiedbyallelicformsoftheIggenesLocationOccurrenceSourceofanti-allotypicAbsIgG1(kappa)Person2IgG1(kappa)Person1HumanImmunoglobulinAllotypesNomenclatureG1m(3)Km(1)HumanImmunoglobulinAllotypesGenetics(alleles)

4、Co-dominantautosomalgenesKm(1)/Km(3)XKm(1)/Km(1)Km(1)/Km(1)andKm(1)/Km(3)AllelicexclusionGenetics(pseudoalleles)Co-dominantG1m(17)G1m(1)214355-358HumanImmunoglobulinAllotypesImmunoglobulinAllotypesDefinitionLocationOccurrenceImportanceMonitoringbonemar

5、rowgraftsForensicmedicinePaternitytestingImmunoglobulinIdiotypesDefinition-UniqueantigenicdeterminantspresentonindividualantibodymoleculesoronmoleculesofidenticalspecificityDNP-BSAStrainAMouseAnti-DNPAbPurifiedanti-DNPAbStrainAMouseAbagainstcombiningsi

6、teofanti-DNPAb??ImmunoglobulinIdiotypesImmunoglobulinIdiotypesDefinitionLocationIgG1(kappa)Person2anti-BIgG1(kappa)Person1anti-AImmunoglobulinIdiotypesDefinitionLocationImportanceVregionmarkerRegulationofimmuneresponsesAgIdanti-Id+-anti-anti-Id+-Regula

7、tionbyId/anti-IdImmunoglobulinIdiotypesDefinitionLocationImportanceVregionmarkerRegulationofimmuneresponsesVaccinesAgIdanti-Id+-Anti-IdiotypeVaccinesAgIdanti-Id+ImmunoglobulinIdiotypesDefinitionLocationImportanceVregionmarkerRegulationofimmuneresponses

8、VaccinesTreatmentofBcelltumors(Tcell)