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时间:2018-10-09
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1、Sleepmedicationlinkedtobizarrebehaviour Newevidencehaslinkedacommonlyprescribedsleepmedicationwithbizarrebehaviours,includingacaseinwhichawomanpaintedherfrontdoorinhersleep. UKandAustralianhealthagencieshavereleasedinformationabout240casesofoddoccurrences,includingsleepwalking,amnesiaandhalluci
2、nationsamongpeopletakingthedrugzolpidem. Whiledoctorssaythatzolpidemcanoffermuch-neededreliefforpeoplewithsleepdisorders,theycautionthatthesenewlyreportedcasesshouldpromptacloserlookatitspossiblesideeffects. Zolpidem,soldunderthebrandnamesAmbien,StilnoctandStilnox,iswidelyprescribedtotreatinsom
3、niaandotherdisorderssuchassleepapnea.Variousformsofthedrug,madebyFrenchpharmaceuticalgiantSanofi-Aventis,wereprescribed674,500timesin2005intheUK. AnewlypublishedreportfromAustralia’sFederalHealthDepartmentdescribes104casesofhallucinationsand62casesofamnesiaexperiencedbypeopletakingzolpidemsincem
4、arketingofthedrugbegantherein2000.Thehealthdepartmentreportalsomentioned16casesofstrangesleepwalkingbypeopletakingthemedication. Midnightsnack Inoneofthesesleepwalkingcasesapatientwokewithapaintbrushinherhandafterpaintingthefrontdoortoherhouse.Anothercaseinvolvedawomanwhogained23kilogramsoverse
5、venmonthswhiletakingzolpidem.“Itwasonlywhenshewasdiscoveredinfrontofanopenrefrigeratorwhileasleepthattheproblemwasresolved,”accordingtothereport. TheUK’sMedicinesandHealthcareproductsRegulatoryAgency,meanwhile,hasrecorded68casesofadversereactionstozolpidemfrom2001to2005. Thenewlyreportedcasesin
6、theUKandAustraliaaddtoagrowinglistofbizarresleepwalkingepisodeslinkedtothedruginothercountries,includingreportsofpeoplesleep-drivingwhileonthemedication.Inonecase,atransatlanticflighthadtobedivertedafterapassengercausedhavocaftertakingzolpidem. Hypnoticeffects Thereisnobiologicalpathwaythathasb
7、eenproventoconnectzolpidemwiththesebehaviours.Thedrugisabenzodiazepine-likehypnoticthatpromotesdeepsleepbyinteractingwithbrainreceptorsforachemicalcalledgamma-aminobutyricacid.Whilepartsofthebrainbecomelessactiveduring
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