妊娠期抗乙型肝炎病毒治疗策略研究进展

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1、授予单位代码10089学号或申请号20153353中国图书分类号R512.6+2HebeiMedicalUniversity硕士学位论文专业学位妊娠期抗乙型肝炎病毒治疗策略研究进展研究生：游晓楠导师：周俊英教授专业：内科学二级学院：第三医院2018年3月目录中文摘要∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙1英文摘要∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙

2、∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙2英文缩写∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙3综述妊娠期抗乙型肝炎病毒治疗策略研究进展∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙4致谢∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙

3、∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙18个人简历∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙∙19中文摘要妊娠期抗乙型肝炎病毒治疗策略研究进展摘要临床研究发现，HBVDNA高载量孕妇应用乙型肝炎疫苗联合乙型肝炎免疫球蛋白（HepatitisBhyper-immuneglobulin,HBIG）阻断母婴传播，仍有部分新生儿免疫失败。但是，在孕期应用抗病毒药物降低血清HBVDNA水平

4、可提高母婴传播阻断率。本文就近年来于HBVDNA高载量孕妇使用核苷（酸）类似物的抗病毒治疗策略、母婴传播阻断成功率、母婴双方的安全性、用药及停药时间等方面作一综述。关键词：肝炎病毒乙型，孕妇，垂直传播，母婴阻断，抗病毒治疗1英文摘要Researchprogressofanti-hepatitisbvirustreatmentstrategyduringpregnancyABSTRACTTheapplicationofhepatitisBvaccinecombinedwithhepatitisBimmunoglobulin(HBIG)stillcannotcompletelyblockingm

5、other-to-childtransmissionofhepatitisB.Atpresent,therearemoreandmorestudiesontheapplicationofnucleosideandnucleotideanologuestoimprovetheeffectofmother-to-childtransmissionblocking.ThisarticlereviewsthestrategiesforantiviraltherapywithnucleosideandnucleotideanologuesforpregnantwomenwithahighHBVDNAl

6、oad,thesuccessrateofinterruptionofmother-to-childtransmission,safetyinmothersandinfants,thetimefordrugadministrationandwithdrawalissues．Keywords:HepatitisBvirus,Pregnancy,Verticaltransmission,Mother-infantblock,Antiviraltreatment2英文缩写英文缩写英文缩写英文全称中文全称HBIGhepatitisbimmunoglobulin乙型肝炎免疫球蛋白HBVHepatitis

7、Bvirus乙型肝炎病毒CHBChronichepatitisB慢性乙型肝炎LAMLamivudine拉米夫定LdTTelbivudine替比夫定TDFTenofovir替诺福韦酯ETVEntecavir恩替卡韦ADVAdefovir阿德福韦酯ALTAlanineTransaminase谷丙转氨酶3综述妊娠期抗乙型肝炎病毒治疗策略研究进展目前，乙型病毒性肝炎仍是我国常见的传染病之一。根据2006年的全国乙型病