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ID:208086
大小:76.50 KB
页数:4页
时间:2017-07-03
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1、Aggrastat-PhaseoftheAGGRASTATtoZOCOR(AtoZ)TrialComparisonofthesafetyandefficacyofunfractionatedheparinversusenoxaparinincombinationwithtirofibanandaspirininindividualswhopresentwithnon-STelevationacutecoronarysyndromesPresentedatACC2003LateBreakingClinicalTrialsBackgro
2、undEnoxaparin(ENOX)hasdemonstratedsuperioritytounfractionatedheparin(UFH)inACSpopulationsmanagedconservativelyintheabsenceofGPIIb/IIIainhibitors(TIMI11,ESSENCE)GPIIb/IIIainhibitorsarenowrecommendedforhighriskACSpatientsinwhomaninvasivestrategyisplannedTrialssuggestaddit
3、ionalbenefitofalowmolecularweightheparin(LMWH)overUFHwhenusedincombinationwithGPIIb/IIIainhibitors(INTERACT)ThegoaloftheAPhaseofAtoZwastocomparethesafetyandefficacyofenoxaparin(ENOX)vsunfractionatedheparin(UFH)incombinationwithtirofibanandaspirininthemanagementofNSTEMI-
4、ACSNon-inferiority=upperboundofone-sided95%CI<1.144UpperBoundOne-Sided95%CIinAtoZ:1.05,Hazardratioof0.88,p=NSNon-inferioritycriteriamet7DayPrimaryEndpointCompositeofDeath,MIandRefractoryIschemiaIncidence(%)PresentedatACC2003LateBreakingClinicalTrialsConclusions:AtoZmeti
5、tsprimaryhypothesis:AmongptswithNSTEMIACStreatedwithtirofibanandASA,Enoxaparinisnon-inferiortoUFHforthecompositeofDeath,MIandRefractoryIschemiaBasedonthedatafromTIMI11,ESSENCE,INTERACTandAtoZ,enoxaparinisanattractivealternativetoheparinwhenusedincombinationwithtirofiban
6、andASASYNERGYwillfurtheraddresstheefficacyofenoxaparinamongpatientstreatedwithanearlyinvasivestrategy
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