CIBIS II研究PPT课件.ppt

《CIBIS II研究PPT课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、CIBISII:CardiacInsufficiencyBisoprololStudyIIPurposeTodeterminewhetherbisoprolol,aβ1-selectiveadrenoreceptorblocker,reducesall-causemortalityinchronicheartfailureReferenceCIBIS-IIInvestigatorsandCommittees.TheCardiacInsufficiencyBisoprololStudyII(CIBIS-II):arandomisedtria

2、l.Lancet1999;353:9–13.CIBISII:CardiacInsufficiencyBisoprololStudyII-TRIALDESIGN-DesignMulticenter,multinational,randomized,double-blind,placebo-controlledPatients2647patients,aged18–80years,withleftventricularejectionfraction<35%andNYHAclassIIIorIVheartfailure,receivingsta

3、ndardtherapy(diureticplusACEinhibitor/othervasodilator)FollowupandprimaryendpointMean1.3yearsfollowup.Primaryendpointall-causemortalityTreatmentPlaceboorbisoprolol1.25mgdaily,increasedstepwiseoverseveralweeksastoleratedtotargetdose10mgdailyCIBISII:CardiacInsufficiencyBiso

4、prololStudyII-RESULTS-Studyhaltedearlybecauseall-causemortalitysignificantlylessinbisoprololgroupthanplacebogroupAlsosignificantreductionin:SuddendeathsAllcardiovasculardeathsAll-causehospitalization,aswellashospitalizationduetoworseningheartfailureTreatmenteffectsindepen

5、dentofseverityorcauseofheartfailureDrugwelltoleratedasdefinedbypermanentearlytreatmentwithdrawals(15%inbothgroups,P=0.98)CIBISII:CardiacInsufficiencyBisoprololStudyII-RESULTScontinued-All-causemortalityCIBIS-IIInvestigatorsandCommittees.Lancet1999;353:9–13.P<0.00010200800

6、6004001.00.80.6DaysafterinclusionSurvivalPlaceboBisoprololCIBISII:CardiacInsufficiencyBisoprololStudyII-RESULTScontinued-PPrimaryendpointAll-causemortalitySecondaryendpointsAll-causehospitaladmissionAllcardiovasculardeathsCombinedendpointExploratoryanalysesSuddendeathHospi

7、taladmissionforworseningheartfailure1739123561812339294120.66(0.54–0.81)0.80(0.71–0.91)0.71(0.56–0.90)0.79(0.69–0.90)0.56(0.39–0.80)0.64(0.53–0.79)<0.00010.00060.00490.00040.00110.0001PrimaryandsecondaryoutcomesCIBIS-IIInvestigatorsandCommittees.Lancet1999;353:9–13.Placebo

8、(n=1320)(%)Bisoprolol(n=1327)(%)Hazardratio(95%CI)CIBISII:CardiacInsufficiencyBisoprololS