EUROPA研究PPT课件.ppt

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1、EuropeantrialonreductionofcardiaceventswithperindoprilinstablecoronaryarterydiseasePresentedatEuropeanSocietyofCardiology2003EUROPATrialPerindopril8mg/dayn=6,110Placebon=6,108Endpoints(follow-upmean3.4years):Primary–CompositeofCVmortality,nonfatalMI,andcardiacarrestSecondary–Comp

2、ositeoftotaldeath,nonfatalMI,andcardiacarrest;heartfailure;revascularization(PCI/CABG);andstrokeEUROPATrialEuropeanSocietyofCardiology200312,218low-riskpatientswithstablecoronaryarterydiseaseRandomized,double-blind,placebo-controlledEUROPATrialCVdeath/non-fatalMI/cardiacarrestp=0

3、.0003EuropeanSocietyofCardiology2003CVMortalityp=0.107EUROPATrialAmongpatientswithstablecoronaryarterydisease,treatmentwiththeACE-Iperindoprilwasassociatedwithareductionintheprimaryendpointofcardiovascularmortality,non-fatalMI,andcardiacarrestcomparedwithplaceboACEinhibitorshavep

4、reviouslybeenshowntobeeffectiveinotherpatientpopulations,includingheartfailure,leftventriculardysfunction,andhigh-riskcoronaryarterydiseasepatientsThepresenttrialisthelargesttoshowabenefitinstable,low-riskCADpatients