【医学ppt课件】细胞因子.ppt

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1、1细胞因子的定义和分类2细胞因子的共同特征和生物学功能。CytokineandcytokinereceptorsChapterIIIHistoryfortheresearchofthecytokinesIn1974，denominatedcytokinecytokinology；internationalcytokinesociety《Cytokine》CompaniesfordevelopingcytokinesinmanycountriesIn1957，Interferon（IFN）wasfoundIn1969，termedlymphokin

2、eMjmacrophageIL-1ActivatedTh1cellaADP56BC58B’CNH2COOHIL-2Cytockinesarelow-molecular-weightregulatoryproteinsorglycoproteinssecretedbywhitebloodcellsandvariouscells(vascularendothelialcell,epidermiccellandfibroblast)inbodyinresponsetoanumberofstimuli.CytokineCytokinegeneInducingstimu

3、lusCytokine-producingcellCytokineGeneactivationReceptorsignalBiologicaleffectsOverviewoftheinductionandfunctionofCytokineSignaltransducersandactivatoroftranscriptionIBiologicaleffectsBiologicaleffectsofthecytokinesAnti-infectionandantitumorImmuneregulationapoptosisStimulatingtheprol

4、iferationanddifferentiationofhemopoieticstemcellsPromotethegrowthanddifferentiationofvariouscellsParticipationandregulationoftheinflammatoryresponsesCytokineabnormalitiesinthepathogenesisincertaindiseasesJustashormonesserveasmessengeroftheendocrinesystem,socytokineseverasmessengerso

5、ftheimmunesystem.Unlikeendocrinehormones,though,whichexerttheireffectsoverlargedistances,cytokinesgeneralactlocally.1.interleukin,IL（白细胞介素）2.colonystimulatingfactor,CSF（集落刺激因子）3.interferon,IFN（干扰素）4.tumornecrosisfactor,TNF（肿瘤坏死因子）5.Chemokine,CK（趋化因子）6.growthfactor,GF（生长因子）IIcytokine

6、sIL-13IL-2IL-41Interleukin,ILInterleukinsaresecretedbysomeleukocytesandactuponotherleukocytes,IL-1~IL-23havebeenidentified.2Colonystimulatingfactor,CSFThecytokinesthatstimulatehemopoieticcellstoformcellcolony,ParticipatehemopoieticfunctionarecalledCSF,forexampleGM-CSF,G-CSF,M-CSF,Ep

7、o,Tpo,G-CSFGM-CSFThefunctionsofCSFThecytokinesthatresistviralinfection,andinterfereviralreplication,includingIFN,IFN(typeI);IFN(typeII)3Interferon,IFNviruscellinfectionIFN-,IFN-IFNIFNTheanti-virusmechanismofIFN-avirusviralreplicationInhibitionofviralreplicationSignal-transduc

8、tionIFN-aIFN-induce