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1、StagingSoftTissueSaraDr.KotilingamisGraduateResearchAssistant,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX.Dr.LevisAssistantProfessorinCancerBiology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX.Dr.LazarisAssistantProfessorinPathology,TheUniversityofTexasMDAnderso
2、nCancerCenter,Houston,TXDr.PollockisDivisionHead,Surgery;Professor,SurgicalOncology;Professor,MolecularandCellularOncology;Chair,SurgicalOncology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX.ABSTRACTSofttissuesara(STS)isanextremelyheterogeneousgroupofraretumorsthatshareap
3、utativemesenchymalcellorigin.STScanoccurinanysofttissueinthebody,yetallshareamonfeatureofprimarilydisseminatinghematogenously,particularlytothelungs.StagingforSTSisparticularlyusefulinprognosis,designofeffectivemultimodalitytreatmentprograms,andparingtreatmentoutesfromdifferentcen
4、tersanddifferenteras.ThecurrentiterationofAJCCSTSstagingincludesTumor,Grade,Node,andMetastasisprovethisprocessexist,particularlyasmolecularconsiderationsbeemoreapparent,andfutureevolutionintoanevenmoreusefulSTSstagingsystemcanbeanticipated.INTRODUCTIONSofttissuesaraisanextremelyra
5、reformofmalignancythatconstituteslessthan1%ofadultsolidmalignancy.Thereareapproximately9,530neorethan50separatehistologicsubtypes,manyoforemoncarcinomas,esenchymalderivationandcaninvolveconnectivetissuestructuresasentanyanbody.Approximatelytity,,abdomen,orotherlocations.Overallsur
6、vivalisapproximately50%at5years;thekeydeterminantofsurvivaliscontrolofbothlocalrecurrenceasination.Dependingonstage,effectivetreatmentusuallyrequiressurgicalextirpationotherapy.STSdisseminatesprimarilyviathehematogenousroute,particularlytothelungs.Althoughdistantmetastasisisanomin
7、ousfinding,theroleofmetastasectomyinbinationentscontinuestoexpand,andpatientsinationhasbeensuccessfullyaddressedinthismanner.Unlikemanyothertypesofmalignancy,localrecurrenceisnotnecessarilyaharbingerofsoon-to-emergesystemicfailure.Indeed,themajorityofpatientsanydisease-freesurvivo
8、rship.Mostsofttissuesarashavenocl
