京尼平巩膜交联对兔实验性形觉剥夺性近视形成的影响

《京尼平巩膜交联对兔实验性形觉剥夺性近视形成的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号16105中国图书分类号R331HebeiMedicalUniversity硕士学位论文学术学位京尼平巩膜交联对兔实验性形觉剥夺性近视形成的影响研究生：赵亚芳导师：王超英教授专业：眼科学二级学院：白求恩国际和平医院2018年3月目录中文摘要····························································································1英文摘要··············································

2、··············································3研究论文京尼平巩膜交联对兔实验性形觉剥夺性近视形成的影响前言····························································································6材料与方法····························································································6结果··········

3、··················································································9附图····························································································11附表····························································································18讨论···

4、·························································································22结论····························································································26参考文献·························································································

5、···26综述京尼平巩膜胶原交联防治病理性近视的研究进展·······················30致谢····························································································38个人简历····························································································39京尼平巩膜交联对兔实验性形觉剥夺性近视形成的影响摘要目前全球近视人

6、口不断增加，近视已成为一种普遍社会现象，大部分近视的发展主要是在学龄期，而在成年后基本稳定。其中高度近视又称病理性近视，所导致的眼轴延长，后巩膜葡萄肿，增加了近视眼的致盲率.这使得数以千万计的国人生活质量显著降低，并消耗了大量的社会资源，因此寻找安全、有效的防治近视的治疗方法，日益成为生命医学科学领域急需解决的一项重大课题。目的：探讨京尼平后Tenon’s囊下注射对兔实验性形觉剥夺性近视形成及发展的影响。方法：14d龄新西兰幼兔40只，雌雄不限，测量双眼屈光度，均以右眼为实验眼，左眼为对照眼。室温20-23℃，白天用自然光照射，光照与黑暗的周期比例为12

7、h:12h。随机分成A、B两组，每组20只，A组为对照组，实验眼行单纯缝合眼睑，B组为实验组，实验眼行眼睑缝合+后Tenon’s囊下注射0.5mmol/L京尼平，第60天拆开实验眼眼睑缝线，测量双眼屈光度，玻璃体腔长度、眼轴长度，闪光视网膜电流图（暗适应3.0和明适应3.0），取实验眼鼻上1：00位和颞下7：00位巩膜及对照眼相应部位巩膜，制作成5mm*10mm的巩膜条带，测量其厚度及弹性模量，蠕变率，极限应力，极限应变。用光学显微镜观察视网膜、视神经、巩膜组织的变化。采用SPSS20.0软件对数据进行配对t检验和独立样本t检验作统计学分析。结果：1.屈

8、光度数和眼轴长度在形觉剥夺实验前，各组实验眼和对照眼比较，屈光度和眼轴长度的差异