急性百草枯中毒大鼠肾脏中细胞因子的表达及乌司他丁对其影响的研究

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1、目录中文摘要····························································································1英文摘要··········································································································4英文缩写······································

2、····································································8研究论文急性百草枯中毒大鼠肾脏中炎性细胞因子的表达及乌司他丁对其影响的研究前言··········································································································9材料与方法································

3、·····························································10结果·········································································································14附图··············································································

4、···························17附表·········································································································29讨论········································································································34结论····

5、················································································39参考文献·································································································40综述百草枯中毒发病机制及治疗的研究进展·········································43致谢···

6、··············································································································54个人简历·········································································································55急性百草枯中毒大鼠肾脏中细胞因子的表达及乌司他丁对其影响的

7、研究摘要目的：百草枯(Paraquat,PQ)，商品名称为对草快、克芜踪，化学名称为1,1’-二甲基-4,4’-联吡啶二氯化物（1,1’-dimethyl-4,4’-dipyridylium）。它除草效果好，遇土失活，对环境不构成污染，因此在农业上广泛使用，PQ中毒人数也日趋升高。自杀、误服都可以造成中毒，一旦中毒，病情就很危重。PQ可以通过不途径进入机体如口服、气道呼吸以及皮肤粘膜的接触。当前，虽然对PQ研究的很透彻，基本达到了分子水平，但有些具体的发病机制和途径还不是很清楚。加之PQ无特效的治疗

8、药物，其病死率甚高，根据很多文献的报道，结合已有的统计资料，估记在80%左右。甚高致死率引起当前国内外中毒专家的广泛关注。PQ进入机体后，主要在肺脏内聚集导致肺组织结构的损伤，但PQ要从哺乳动物的肾脏代谢出体外，所以肾功能的好坏对于PQ中毒患者来说，极其关键。近年来，随着研究的深入，推测PQ肺损伤很有可能与氧自由基引起氧化应激反应、炎性细胞介质、因子的释放、细胞凋亡及DNA损伤等有关系。本研究已经建立了大鼠中毒模型，观察肾组织结构病理学的损伤，测定血浆中尿素氮(BUN