99tcm标记zher2%3av2-培美曲塞在人肺腺癌荷瘤裸鼠体内分布及显像的实验研究

《99tcm标记zher2%3av2-培美曲塞在人肺腺癌荷瘤裸鼠体内分布及显像的实验研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、授予单位代码10089学号或申请号20152226中国图书分类号R445.5HebeiMedicalUniversity硕士学位论文学术学位99Tcm标记ZHER2:V2-培美曲塞在人肺腺癌荷瘤裸鼠体内分布及显像的实验研究研究生：刘嘉晖导师：赵新明教授专业：影像医学与核医学二级学院：第四医院2018年3月目录中文摘要············································································································1英文摘要···················

2、·························································································4英文缩写············································································································7研究论文99Tcm标记ZHER2:V2-培美曲塞在人肺腺癌荷瘤裸鼠体内分布及显像的实验研究前言·········································

3、···································································8材料与方法································································································9结果··········································································································12附图·········

4、·································································································16附表··········································································································25讨论················································································

5、··························28结论··········································································································31参考文献··································································································31综述分子影像对肺癌诊疗的研究进展·································

6、·····················33致谢··················································································································72个人简历··········································································································73中文摘要99Tcm标记ZHER2:V2-培美曲塞在人肺腺癌荷瘤裸鼠体内分布及

7、显像的实验研究摘要目的：本研究将制备人表皮生长因子受体2（Humanepidermalgrowthreceptor2,HER2）亲合体分子影像探针99Tcm-ZHER2:V2-培美曲塞，研究3种不同HER2表达情况的人肺腺癌H2009、A549及H23细胞荷瘤裸鼠体内分布和显像，并进行对比分析，探讨99Tcm-ZHER2:V2-培美曲塞在靶向诊疗一体化分子探针在HER2高表达肺腺癌中的靶向摄取特性和诊断价值。方法：应用随机数字表法取12只H2009荷瘤裸鼠，利用随机数字表法随机分为4组，每组为3只；各组