测定低密度脂蛋白正常急性冠脉综合征患者心型脂肪酸结合蛋白并c反应蛋白意义

《测定低密度脂蛋白正常急性冠脉综合征患者心型脂肪酸结合蛋白并c反应蛋白意义》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、【摘要】目的：探讨在低密度脂蛋白胆固醇(LDLC)水平正常的急性冠脉综合征(ACS)患者联合测定心型脂肪酸结合蛋白(h-FABP)，并超敏C-反应蛋白(hs-CRP)的临床意义。方法：测定28例经冠脉造影排除冠心病的住院患者(对照组)和84例经冠状动脉造影确诊为ACS且LDLC正常的患者(ACS组)的h-FABP，比较两组间的阳性率。同时测定两组hs-CRP水平，比较其差异，ACS患者又被分为不稳定型心绞痛(UAP)、非ST段抬高型心肌梗塞(NSTEMI)、ST段抬高型心肌梗塞(STEMI)三组，比较各组间hs-CRP水平。结果：ACS患者h-FABP阳性率(72.6

2、%)显著高于对照组的(7.1%)P<0.01。ACS患者的hs-CRP水平明显高于对照组[(27.42±12.70)mg/L∶(4.95±3.14)mg/L，P<0.05]，且随着病变进一步进展，其水平亦升高，组间差异显著(P均<0.05)。结论：h-FABP联合hs-CRP可提高ACS早期诊断的准确性，同时hs-CRP水平能预测病变的进展程度。【关键词】心型脂肪酸结合蛋白;C反应蛋白质;冠状动脉疾病;冠状血管造影术　clinicalsignificancedetectedheartfattyacidbindingproteinandhighsensitiveCrea

3、ctiveproteininacutecoronarysyndromepatientswithnormallowdensitylipoproteinlevel/LIUTianhua,LIUXinbing,FANGXuchen,TUChunlian,JIANGBojie,SHENLi,WUYan,ZHAOZhongmou,YEXuhui//DepartmentofCardiology,ShidongHospitalofShanghai,Shanghai,200438,China　　Abstract：Objective:Toinvestigatetheclini

4、calsignificancedetectedheartfattyacidbindingprotein(h-FABP)andhighsensitiveCreactiveprotein(hs-CRP)inacutecoronarysyndrome(ACS)patientswithnormallowdensitylipoprotein(LDL)level.Methods:Theh-FABPwasmeasuredin28patientswhowereeliminatedcoronaryheartdiseasebycoronaryangiography(controlgrou

5、p)and84patientswithacutecoronarysyndrome(ACS)bycoronaryangiographybutwithnormalLDLlevel(observationgroup)，andcomparedtheh-FABPpositiverateintwogroups.Alsothehs-CRPconcentrationsweremeasuredintwogroups,comparedtheirdisparities.TheACSpatientsweredividedintothreegroupsincludingunstableangina

6、(UAP),non-STelevatedmyocardialinfarction(NSTEMI)，STelevatedmyocardialinfarction(STEMI),comparedthehs-CRPconcentrationineachgroup.Results:Thepositiverateofh-FABPinACSgroup(72.6%)wasmorethanthatincontrolgroup(7.1%),P<0.05.Thelevelofhs-CRPinACSgroupwasmuchhigherthanthatincontrolgroup[(27.42±

7、12.70)mg/L∶(4.95±3.14)mg/L，P<0.05],thesevererofpathologicalchange,thehigherofconcentrationofhs-CRP(P<0.05).Conclusion:Detecth-FABPandhs-CRPcanimprovetheaccuracyofearlydiagnosisofACS,furthermore,theconcentrationofhs-CRPmaypredictthedegreeofpathologicalchange.　　Keywor